{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:12:45Z","timestamp":1788567165351,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":46,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Japan has a high incidence of gastric cancer and is currently the only nation in which guidelines recommend\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n screening for adolescents. However, the implementation and implications of these initiatives have not been comprehensively characterized. The aim of this study was to provide a comprehensive overview of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening programs for adolescents in Japan.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n A narrative review was conducted to summarize the studies on\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening among adolescents in Japan. Literature searches were performed in PubMed, Ichushi\u2010Web, CiNii Research, and J\u2010STAGE for articles published up to February 12, 2026. Studies that described\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening programs targeting adolescents in Japan were included. Data were extracted on study background and objectives, target age, screening methods, participation rates, infection prevalence, eradication regimens, eradication success rates, and adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seventeen studies met the inclusion criteria. Screening programs were typically local\u2010government\u2010led and school\u2010based and primarily targeted junior high school students. A two\u2010step diagnostic strategy employing noninvasive tests was commonly used. The median prevalence of\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n infection was 3.1%. Eradication regimens varied across programs; metronidazole\u2010 or vonoprazan\u2010containing regimens generally showed higher eradication success rates than proton pump inhibitor\u2010based clarithromycin\u2010containing regimens, although cross\u2010study comparisons should be interpreted cautiously because of heterogeneity. Adverse events were generally mild and predominantly gastrointestinal, and no serious complications were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Local\u2010government\u2010led and school\u2010based\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n screening among adolescents in Japan represents a feasible approach to the prevention of gastric cancer within a well\u2010established school health system. The applicability of this strategy to other countries depends on several contextual factors, including the incidence of gastric cancer, health care infrastructure, and the presence of organized school health systems. In settings that lack these conditions, alternative community\u2010based strategies may be required.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hel.70159","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T17:54:12Z","timestamp":1786902852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["School\u2010Based\n Helicobacter pylori<\/i>\n Screening for Adolescents in Japan: Current Status, Challenges, and Implications: A Narrative Review"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7517-0172","authenticated-orcid":false,"given":"Eisuke","family":"Kameoka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0824-454X","authenticated-orcid":false,"given":"Hiroaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Japan"},{"name":"Department of Internal Medicine Soma Central Hospital Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-1557","authenticated-orcid":false,"given":"Takuto","family":"Hikichi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Fukushima Medical University Hospital Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-1778","authenticated-orcid":false,"given":"Jun","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"},{"name":"Department of Endoscopy Fukushima Medical University Hospital Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-2463","authenticated-orcid":false,"given":"Tsunetaka","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"},{"name":"Department of Endoscopy Fukushima Medical University Hospital Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1236-857X","authenticated-orcid":false,"given":"Takumi","family":"Yanagita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"},{"name":"Department of Endoscopy Fukushima Medical University Hospital Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3935-8478","authenticated-orcid":false,"given":"Mitsuru","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-7364","authenticated-orcid":false,"given":"Masao","family":"Kobayakawa","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Fukushima Medical University Hospital Fukushima Japan"},{"name":"Medical Research Center Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-202X","authenticated-orcid":false,"given":"Masaharu","family":"Tsubokura","sequence":"additional","affiliation":[{"name":"Department of Radiation Health Management Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-0634","authenticated-orcid":false,"given":"Hiromasa","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70090"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010320839"},{"key":"e_1_2_11_5_1","unstructured":"National Cancer Center Japan \u201cStomach Cancer Statistics \u201d National Cancer Center Cancer Information Service 2026 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M.","year":"2024","journal-title":"Japanese Helicobacter Society Journal"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102021\u2010325630"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2019.22.5.417"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpn3.12314"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.70063"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.70002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010026\u201002379\u20104"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41073\u2010019\u20100064\u20108"},{"issue":"3","key":"e_1_2_11_19_1","first-page":"135","article-title":"Helicobacter pylori\n Screening Among Young Individuals in Saga Prefecture: A Gastric Cancer Prevention Project for the Future","volume":"84","author":"Kakiuchi T.","year":"2025","journal-title":"Journal of Child Health"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.70067"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010025\u201002236\u2010w"},{"issue":"1","key":"e_1_2_11_22_1","first-page":"13","article-title":"Current Status and Challenges of \n Helicobacter pylori\n Screening Among Junior High School Students in Saijo City, Ehime Prefecture","volume":"3","author":"Kusumoto T.","year":"2022","journal-title":"Journal of Ehime Pediatric Association"},{"issue":"1","key":"e_1_2_11_23_1","first-page":"84","article-title":"Six\u2010Year Results of a Screening System for Second\u2010Year Junior High School Students Using Serum \n Helicobacter pylori\n Antibody Titers","volume":"60","author":"Ono K.","year":"2021","journal-title":"Yamagata Medical 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M.","year":"2018","journal-title":"Donan Medical Journal"},{"key":"e_1_2_11_29_1","first-page":"51","article-title":"Helicobacter pylori\n Screening Among Junior High School Students as a Medical Association Project: First Report Toward Elimination of Gastric Cancer in the Region","volume":"1","author":"Kosen K.","year":"2018","journal-title":"Donan Medical Journal"},{"issue":"106","key":"e_1_2_11_30_1","first-page":"8","article-title":"Kyoto Prefecture High School First\u2010Grade \n Helicobacter pylori\n Project","volume":"1","author":"Handa O.","year":"2018","journal-title":"Schneller"},{"issue":"1","key":"e_1_2_11_31_1","first-page":"21","article-title":"Helicobacter pylori\n Screening Among Junior High School Students in Abashiri City","volume":"65","author":"Sasaki Y.","year":"2017","journal-title":"Clinics in Pediatric Medicine"},{"issue":"3","key":"e_1_2_11_32_1","first-page":"14","article-title":"Helicobacter pylori\n Screening and Eradication Therapy Among Junior High School 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Y.Park \u201cPopulation\u2010BasedHelicobacter pyloriScreen\u2010and\u2010Treat Strategies for Gastric Cancer Prevention: Guidance on Implementation \u201d IARC Working Group Reports 2026 https:\/\/publications.iarc.fr\/Book\u2010And\u2010Report\u2010Series\/Iarc\u2010Working\u2010Group\u2010Reports\/Population\u2010Based\u2010Helicobacter\u2010Pylori\u2010Screen\u2010and\u2010Treat\u2010Strategies\u2010For\u2010Gastric\u2010Cancer\u2010Prevention\u2010Guidance\u2010On\u2010Implementation\u20102025."},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2509254"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.70196"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.02.010"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hel.70159","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hel.70159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:08:06Z","timestamp":1788149286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hel.70159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hel.70159"],"URL":"https:\/\/doi.org\/10.1111\/hel.70159","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70159"}}