{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:52:49Z","timestamp":1791175969841,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric cancer (GC) remains a major cause of cancer\u2010related mortality worldwide, with prognosis and treatment costs strongly influenced by disease stage at diagnosis. Endoscopic GC screening has been proposed for intermediate\u2010to\u2010high\u2010risk countries, although its economic feasibility remains uncertain. This study evaluated the costs associated with opportunistic GC screening integrated into a colorectal cancer screening programme and compared modeled early\u2010stage management scenarios with the real\u2010world costs of managing Stages II\u2013IV disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cost\u2010comparison study was conducted from the perspective of the Portuguese National Health Service. Screening costs were derived from 377 fecal immunochemical testing\u2010positive individuals undergoing one\u2010time opportunistic esophagogastroduodenoscopy (EGD) during colonoscopy within the organized colorectal cancer screening programme, and treatment costs from a retrospective cohort of 222 patients with gastric adenocarcinoma. Direct medical costs were analyzed according to disease stage and compared with two modeled early\u2010stage management scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gastric precancerous conditions were identified in 46.9% of screened individuals, and gastric adenocarcinoma was detected in 0.8% (3\/377). The estimated screening cost was \u20ac17,249 per cancer detected. Mean treatment and follow\u2010up costs per patient were \u20ac32,140 for Stage II disease, \u20ac33,073 for Stage III disease, and \u20ac19,287 for Stage IV disease. The estimated cumulative cost of screening followed by ESD was \u20ac27,624, whereas screening followed by surgical treatment of Stage I disease was estimated at \u20ac44,493.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GC management is associated with substantial healthcare expenditure. The potential economic value of opportunistic GC screening is likely to depend on the detection of lesions amenable to endoscopic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trail Registration<\/jats:title>\n                    <jats:p>NCT07522320.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hel.70161","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:25:33Z","timestamp":1791174333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Opportunistic Gastric Cancer Endoscopic Screening Integrated Into Population\u2010Based Colorectal Cancer Screening: A Retrospective Economic Cost\u2010Comparison Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-1560","authenticated-orcid":false,"given":"B.","family":"Mourato","sequence":"first","affiliation":[{"name":"NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, LA\u2010REAL, CCAL NOVA University Lisbon  Lisbon Portugal"},{"name":"Unidade Local de Sa\u00fade Do Alto Alentejo Hospital Doutor Jos\u00e9 Maria Grande  Portalegre Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8270-992X","authenticated-orcid":false,"given":"P.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade Do Alto Alentejo Hospital Doutor Jos\u00e9 Maria Grande Portalegre  Portalegre 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