{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:41:56Z","timestamp":1771954916477,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T00:00:00Z","timestamp":1353974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Aim<\/jats:title>Biliary atresia (BA<\/jats:styled-content>) is a neonatal liver disease defined as chronic progressive fibrotic obliteration of extrahepatic bile ducts. The objective of this study was to determine the association of serum connective tissue growth factor (CTGF<\/jats:styled-content>) with clinical outcome and liver stiffness measurement.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty\u2010two BA<\/jats:styled-content> patients post\u2010Kasai operation and 28 healthy controls were recruited. BA<\/jats:styled-content> patients were categorized into two groups based on their portal hypertension (PH<\/jats:styled-content>) status. Serum CTGF<\/jats:styled-content> levels were determined by enzyme\u2010linked immunosorbent assay. Liver stiffness scores were measured by transient elastography.<\/jats:p><\/jats:sec>Results<\/jats:title>BA<\/jats:styled-content> patients had greater CTGF<\/jats:styled-content> levels (905.9\u2009\u00b1\u200957.7 vs 238.3\u2009\u00b1\u200923.5\u2009pg\/mL, P<\/jats:italic>\u2009<\u20090.001) and higher liver stiffness values than controls (28.2\u2009\u00b1\u20092.6 vs 5.0\u2009\u00b1\u20090.5\u2009kPa, P<\/jats:italic>\u2009<\u20090.001). Serum CTGF<\/jats:styled-content> levels were remarkably elevated in BA<\/jats:styled-content> patients with PH<\/jats:styled-content> compared to those without PH<\/jats:styled-content> (1092.4\u2009\u00b1\u200973.9 vs 582.6\u2009\u00b1\u200945.7\u2009pg\/mL, P<\/jats:italic>\u2009<\u20090.001). Furthermore, BA<\/jats:styled-content> patients with PH<\/jats:styled-content> had significantly higher liver stiffness values compared to those without PH<\/jats:styled-content> (37.3\u2009\u00b1\u20093.0 vs 10.6\u2009\u00b1\u20091.1\u2009kPa, P<\/jats:italic>\u2009<\u20090.001). Additionally, serum CTGF<\/jats:styled-content> was positively correlated with liver stiffness (r<\/jats:italic>\u2009=\u20090.875, P<\/jats:italic>\u2009<\u20090.001) and total bilirubin (r<\/jats:italic>\u2009=\u20090.462, P<\/jats:italic>\u2009<\u20090.001). There was an inverse correlation between serum CTGF<\/jats:styled-content> and serum albumin (r<\/jats:italic>\u2009=\u2009\u22120.579, P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>High serum CTGF<\/jats:styled-content> was associated with a poor outcome in BA<\/jats:styled-content> patients. Accordingly, serum CTGF<\/jats:styled-content> and transient elastography may serve as non\u2010invasive biomarkers reflecting the disease severity in postoperative BA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12015","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T12:52:26Z","timestamp":1353675146000},"page":"795-800","source":"Crossref","is-referenced-by-count":12,"title":["Correlation of connective tissue growth factor with liver stiffness measured by transient elastography in biliary atresia"],"prefix":"10.1111","volume":"43","author":[{"given":"Sittisak","family":"Honsawek","sequence":"first","affiliation":[{"name":"Department of Biochemistry Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanvisa","family":"Udomsinprasert","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chintana","family":"Chirathaworn","sequence":"additional","affiliation":[{"name":"Department of Microbiology Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilai","family":"Anomasiri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paisarn","family":"Vejchapipat","sequence":"additional","affiliation":[{"name":"Department of Surgery Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Poovorawan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology Department of Pediatrics Faculty of Medicine Chulalongkorn University King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok 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