{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:58:42Z","timestamp":1778810322635,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>A rapid and non\u2010invasive method of detecting fibrosis in patients with chronic liver diseases is of major clinical interest. The purpose of this study was to comparatively investigate the effectiveness of the<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ibrosis<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex) calculated using real\u2010time tissue elastography (<jats:styled-content style=\"fixed-case\">RTE<\/jats:styled-content>) in patients with non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) and patients with chronic hepatitis<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven patients with biopsy\u2010proven<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>and 93 patients with biopsy\u2010proven<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>were included. They underwent transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>), serum liver fibrosis marker testing and<jats:styled-content style=\"fixed-case\">RTE<\/jats:styled-content>to calculate the<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex showed a stepwise increase with increasing histological severity of fibrosis in<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>patients (<jats:italic>P<\/jats:italic>= 0.0102), whereas no significant correlation of the<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex with the histological severity of liver fibrosis in<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>patients (<jats:italic>P<\/jats:italic>= 0.852). There was a significant correlation between the<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex and liver stiffness measured by<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>in<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>patients (<jats:italic>r<\/jats:italic>= 0.319,<jats:italic>P<\/jats:italic>= 0.0009). On the other hand, no such correlation was observed in<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>patients. While in<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>patients, the<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex was correlated with the<jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 index, no such correlation was observed in<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The<jats:styled-content style=\"fixed-case\">LF I<\/jats:styled-content>ndex calculated by<jats:styled-content style=\"fixed-case\">RTE<\/jats:styled-content>is effective for assessment of liver fibrosis in patients with<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>. On the other hand, it is not useful in patients with<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. This is the first study to compare the clinical usefulness of<jats:styled-content style=\"fixed-case\">RTE<\/jats:styled-content>as non\u2010invasive assessment of liver fibrosis between<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. Further investigations are required to refine statistical assessment of<jats:styled-content style=\"fixed-case\">RTE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12023","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T22:05:30Z","timestamp":1352757930000},"page":"735-742","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of the<scp>L<\/scp>iver<scp>F<\/scp>ibrosis<scp>I<\/scp>ndex calculated by using real\u2010time tissue elastography for the non\u2010invasive assessment of liver fibrosis in chronic liver diseases"],"prefix":"10.1111","volume":"43","author":[{"given":"Wataru","family":"Tomeno","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Imajo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Mawatari","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shibata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kirikoshi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011775"},{"issue":"7","key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","article-title":"Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease","volume":"55","author":"Ludwig J","year":"1980","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"e_1_2_5_4_1","first-page":"S11","article-title":"Natural history of nonalcoholic steatohepatitis","volume":"40","author":"Liou I","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1308-3"},{"issue":"5","key":"e_1_2_5_6_1","first-page":"S3","article-title":"National Institutes of Health Consensus Development Conference statement: management of hepatitis C, 2002\u2010June 10\u201012, 2002","volume":"36","author":"National Institutes of Health","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102153440706"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0322"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0301-x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10100319"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122602"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252789"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36572"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12925"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01377.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2003.07.001"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.077"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00440-9"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00191-0"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06038.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.084"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.126417"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.10.019"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25756"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T18:59:12Z","timestamp":1745175552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,6]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/hepr.12023"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12023","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,6]]}}}