{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:36:31Z","timestamp":1769074591018,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>We report a case of idiopathic portal hypertension (<jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>) complicated with autoimmune hepatitis. A 60\u2010year\u2010old woman was admitted to our hospital with esophageal and gastric varices in <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2010. Abdominal ultrasonography and computed tomography showed splenomegaly and collateral veins without evidence of liver cirrhosis. Laboratory examinations and liver biopsy indicated that the esophageal and gastric varices were caused by <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>. She underwent endoscopic injection sclerotherapy and partial splenic embolization. Two years after these therapies, laboratory examinations showed liver dysfunction with elevated levels of aspartate aminotransferase (180\u2009<jats:styled-content style=\"fixed-case\">IU\/L<\/jats:styled-content>), alanine aminotransferase (190\u2009<jats:styled-content style=\"fixed-case\">IU\/L<\/jats:styled-content>), \u03b3\u2010glutamyl transpeptidase (159\u2009<jats:styled-content style=\"fixed-case\">IU\/L<\/jats:styled-content>) and immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> (2609\u2009mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>). The titer of antinuclear antibodies was 1:320 and its pattern was homogeneous and speckled. Histological examination revealed plasma cell\/lymphocyte infiltration and interface hepatitis in the portal tract. Based on these findings, a diagnosis of autoimmune hepatitis accompanied by <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> was made. After treatment with prednisolone (20\u2009mg\/day), liver functions were normalized immediately. Overlapping of <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> is extremely rare, but the present case is interesting considering the etiology of <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content> because an autoimmune mechanism is thought to be involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">IPH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hepr.12038","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T03:45:13Z","timestamp":1368675913000},"page":"984-990","source":"Crossref","is-referenced-by-count":7,"title":["Case of idiopathic portal hypertension complicated with autoimmune hepatitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Kazumichi","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Katsushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Monoe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"53","volume-title":"Report of the Research Committee on Portal Venopathy of Ministry of Health, Labor and Welfare 2000","author":"Sugimachi K","year":"2001"},{"key":"e_1_2_4_3_1","first-page":"31","article-title":"A case of idiopathic portal hypertension complicated with narrowing of intrahepatic bile ducts","volume":"42","author":"Hikichi T","year":"1996","journal-title":"Fukushima J Med Sci"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.06.001"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-006-0456-8"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10165-006-0465-7"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604043341406"},{"key":"e_1_2_4_8_1","unstructured":"The Japanese Society of Portal Hypertension.The general rule for the study of portal hypertension.2004."},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22322"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI100883"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1982.tb00195.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196510000-00006"},{"key":"e_1_2_4_14_1","first-page":"336","article-title":"Non\u2010cirrhotic portal hypertension; a new syndrome I. 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