{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:54:44Z","timestamp":1780052084415,"version":"3.53.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>There have been some reports on the use of paired biopsies for monitoring disease progression in non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) patients. Recently, transient elastography has been developed as a non\u2010invasive method for predicting the severity of liver fibrosis. We investigated 4\u2010year disease progression in <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients by evaluating liver stiffness measurements (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) obtained using transient elastography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 97 biopsy\u2010proven <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients whose <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> were obtained 4 years prior, we revaluated 36 who were available for follow up and compared their current stage of fibrosis with that at initial assessment. Fibrosis stage was diagnosed according to the cut\u2010off values previously reported by our institution. We also investigated correlations between changes in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and changes in non\u2010invasive fibrosis markers obtained by performing biochemical tests and clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of nine (25%) patients had fibrosis progression, 17 (47.2%) had static disease and 10 (27.8%) had fibrosis remission. Among patients with stage 0 fibrosis as per initial <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200916), 11 had static disease and five had fibrosis progression according to <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> obtained 4 years later. Changes in <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> correlated with changes in the <jats:styled-content style=\"fixed-case\">FIB4<\/jats:styled-content> index (<jats:italic>R<\/jats:italic>\u2009=\u20090.519, <jats:italic>P<\/jats:italic>\u2009=\u20090.0011) and aspartate aminotransferase\u2010to\u2010platelet ratio index (<jats:italic>R<\/jats:italic>\u2009=\u20090.346, <jats:italic>P<\/jats:italic>\u2009=\u20090.0412), but not with changes in other non\u2010invasive markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transient elastography is non\u2010invasive and easy to use; therefore, it can be a useful tool for monitoring the severity of hepatic fibrosis in <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12039","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T13:35:42Z","timestamp":1354887342000},"page":"979-983","source":"Crossref","is-referenced-by-count":29,"title":["Transient elastography for monitoring the fibrosis of non\u2010alcoholic fatty liver disease for 4 years"],"prefix":"10.1111","volume":"43","author":[{"given":"Kaori","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Imajo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Yokohama 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