{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:13:06Z","timestamp":1757452386660},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive Japanese patients with hepatic cirrhosis due to hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> who had undergone elective splenectomy in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>yushu <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2008 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2009 were included in this retrospective study. Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prothrombin time and total serum bilirubin concentration improved after splenectomy; however, serum albumin concentrations did not increase significantly. Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3\u2009mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. Multiple linear regression analysis identified hepatic vein waveform (<jats:styled-content style=\"fixed-case\">HVWF<\/jats:styled-content>) type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090.0174) and spleen weight (<jats:italic>P<\/jats:italic>\u2009=\u20090.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002) as the only independent predictor of decrease in total bilirubin. Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with <jats:styled-content style=\"fixed-case\">HVWF<\/jats:styled-content> type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>, however, they were not improved in patients with <jats:styled-content style=\"fixed-case\">HVWF<\/jats:styled-content> type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. <jats:styled-content style=\"fixed-case\">HVWF<\/jats:styled-content> type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12040","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T17:44:05Z","timestamp":1355420645000},"page":"933-941","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus\u2010related cirrhotic patients"],"prefix":"10.1111","volume":"43","author":[{"given":"Nao","family":"Kinjo","sequence":"first","affiliation":[{"name":"Department of Surgery and Science Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Surgery and Science Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Akahoshi","sequence":"additional","affiliation":[{"name":"Department of 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