{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:50:27Z","timestamp":1761972627945,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Aim<\/jats:title>The aim of this survey was to reveal clinical features for each etiology of non\u2010B<\/jats:styled-content>, non\u2010C<\/jats:styled-content> liver cirrhosis (NBNC LC<\/jats:styled-content>) in J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>Methods<\/jats:title>I<\/jats:styled-content>n a nationwide survey of NBNC LC<\/jats:styled-content> in J<\/jats:styled-content>apan at the 15th G<\/jats:styled-content>eneral M<\/jats:styled-content>eeting of the J<\/jats:styled-content>apan S<\/jats:styled-content>ociety of H<\/jats:styled-content>epatology, 6999 NBNC LC<\/jats:styled-content> patients were registered at 48 medical institutions. Epidemiological and clinical factors were investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>The percentage of NBNC LC<\/jats:styled-content> among LC<\/jats:styled-content> patients was 26%. NBNC LC<\/jats:styled-content> patients were categorized into 11 types according to etiological agents: non\u2010alcoholic steatohepatitis (NASH<\/jats:styled-content>), 14.5%; alcoholic liver disease (ALD<\/jats:styled-content>), 55.1%; fatty liver disease (FLD<\/jats:styled-content>), except NASH<\/jats:styled-content>, ALD<\/jats:styled-content>, and other known etiology, 2.5%; primary biliary cirrhosis, 8.0%; other biliary cirrhosis, 0.8%; autoimmune hepatitis, 6.8%; metabolic disease, 0.6%; congestive disease, 0.8%; parasitic disease, 0.2%; other known etiology, 0.2%; and unknown etiology, 10.5%. Compared with previous surveys, the percentage of ALD<\/jats:styled-content> remained unchanged, whereas that of NASH<\/jats:styled-content> increased. The mean age and percentage of females were significantly higher in NASH<\/jats:styled-content> patients than in ALD<\/jats:styled-content> and FLD<\/jats:styled-content> patients. Prevalence of diabetes mellitus was significantly higher in NASH<\/jats:styled-content> and FLD<\/jats:styled-content> patients than in ALD<\/jats:styled-content> ones. Prevalence of hepatocellular carcinoma (HCC<\/jats:styled-content>) in NBNC LC<\/jats:styled-content> patients was 35.9%. Among NASH<\/jats:styled-content>, ALD<\/jats:styled-content> and FLD<\/jats:styled-content> patients, 50.9%, 34.3% and 54.5% had HCC<\/jats:styled-content>, respectively. Positivity of hepatitis B<\/jats:styled-content> core antibody was significantly higher in HCC<\/jats:styled-content> patients than in those without HCC<\/jats:styled-content> (41.1% vs 24.8%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This survey determined the etiology of NBNC LC<\/jats:styled-content> in J<\/jats:styled-content>apan. These results should contribute new ideas toward understanding NBNC LC<\/jats:styled-content> and NBNC HCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12056","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T12:32:20Z","timestamp":1356525140000},"page":"1020-1031","source":"Crossref","is-referenced-by-count":22,"title":["Survey of non\u2010B<\/scp>, non\u2010C<\/scp> liver cirrhosis in J<\/scp>apan"],"prefix":"10.1111","volume":"43","author":[{"given":"Yasuaki","family":"Suzuki","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hematology\/Oncology Department of Medicine Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Ohtake","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hematology\/Oncology Department of Medicine Asahikawa Medical University Asahikawa 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