{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T10:01:42Z","timestamp":1707904902575},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Aim<\/jats:title>\u2002Although perihepatic lymph node enlargement (PLNE<\/jats:styled-content>) is reportedly associated with the negative outcome of interferon therapy for chronic hepatitis C<\/jats:styled-content>, there were limitations in that the results were obtained in patients with various genotypes, viral loads and treatment regimens. We aimed to precisely clarify the significance of PLNE<\/jats:styled-content> in interferon therapy for chronic hepatitis C<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>\u2002Between D<\/jats:styled-content>ecember 2004 and J<\/jats:styled-content>une 2005, 112 patients with hepatitis C<\/jats:styled-content> virus (HCV<\/jats:styled-content>) genotype 1 and HCV RNA <\/jats:styled-content>of more than 100\u2009KIU<\/jats:styled-content>\/mL<\/jats:styled-content> were enrolled, who underwent pegylated interferon\u2010\u03b1 plus ribavirin therapy thereafter. PLNE<\/jats:styled-content> was defined as a perihepatic lymph node of more than 1\u2009cm in the longest axis by ultrasonography.<\/jats:p><\/jats:sec>Results<\/jats:title>\u2002The sustained virological response (SVR<\/jats:styled-content>) rate was lower in patients with PLNE<\/jats:styled-content> (4\/22, 18.2%) than in those without (37\/90, 41.1%; P<\/jats:italic>\u2009=\u20090.045) and viral load decline was smaller in patients with PLNE<\/jats:styled-content> than in those without (P<\/jats:italic>\u2009=\u20090.028). The proportion of PLNE<\/jats:styled-content> positive patients was the smallest in the SVR<\/jats:styled-content> group (P<\/jats:italic>\u2009=\u20090.033) among the patient groups divided by the treatment outcome. PLNE<\/jats:styled-content> was retained as a negative predictor for SVR<\/jats:styled-content> by multivariate logistic regression analysis (P<\/jats:italic>\u2009=\u20090.012). Furthermore, PLNE<\/jats:styled-content> was not significantly associated with the mutations at HCV<\/jats:styled-content> core protein and at interferon sensitivity\u2010determining region, or interleukin\u201028B<\/jats:styled-content> polymorphism in 45 patients with HCV<\/jats:styled-content> genotype 1, enrolled between D<\/jats:styled-content>ecember 2011 and M<\/jats:styled-content>arch 2012.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>\u2002PLNE<\/jats:styled-content> is a negative predictor for SVR<\/jats:styled-content> in patients with HCV<\/jats:styled-content> genotype 1 and HCV RNA <\/jats:styled-content>of more than 100\u2009KIU<\/jats:styled-content>\/mL<\/jats:styled-content> treated with pegylated interferon\u2010\u03b1 plus ribavirin, independent of other known predictors for SVR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12061","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T14:29:26Z","timestamp":1357223366000},"page":"1005-1012","source":"Crossref","is-referenced-by-count":3,"title":["Perihepatic lymph node enlargement is a negative predictor for sustained responses to pegylated interferon\u2010\u03b1 and ribavirin therapy for J<\/scp>apanese patients infected with hepatitis C<\/scp> virus genotype 1"],"prefix":"10.1111","volume":"43","author":[{"given":"Hiromi","family":"Hikita","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Enooku","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine The University of Tokyo Tokyo Japan"},{"name":"Department of Gastroenterology Graduate School of Medicine The 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