{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:10:45Z","timestamp":1723065045118},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Aim<\/jats:title>The aim of this study was to evaluate the efficacy and safety of combination therapy using natural human interferon\u2010\u03b2 and ribavirin (IFN<\/jats:styled-content>\u2010\u03b2\/RBV<\/jats:styled-content>) for chronic hepatitis C<\/jats:styled-content> patients who were injection drug users (IDU<\/jats:styled-content>) and resident in the A<\/jats:styled-content>irin district of O<\/jats:styled-content>saka, containing the biggest slums in J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twenty\u2010nine IDU<\/jats:styled-content> with chronic hepatitis C<\/jats:styled-content> received combination therapy of IFN<\/jats:styled-content>\u2010\u03b2\/RBV<\/jats:styled-content>. The psychiatrist in charge evaluated the scores of the Z<\/jats:styled-content>ung S<\/jats:styled-content>elf\u2010rating D<\/jats:styled-content>epression S<\/jats:styled-content>cale (SDS<\/jats:styled-content>), a self\u2010rating scale based on 20 questions. Univariate logistic regression analyses were used to determine the factors that significantly contributed to complete treatment and a sustained virological response (SVR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Thirteen of the 29 patients achieved SVR<\/jats:styled-content> according to the intention to treat analysis. All patients with a rapid virological response achieved SVR<\/jats:styled-content>. No patient required a reduced dose of RBV<\/jats:styled-content> because of a decrease in their hemoglobin level, or of IFN<\/jats:styled-content>\u2010\u03b2 because of a low level of white blood cells and platelet count. Two patients had psychological side\u2010effects and stopped the therapy early in the treatment; one patient had depression and the other had anxious depression. Univariate logistic regression analyses indicated that the stage of fibrosis was the only factor that contributed to SVR<\/jats:styled-content>, and that the SDS<\/jats:styled-content> test and past drug abuse contributed to completion of the treatment.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IFN<\/jats:styled-content>\u2010\u03b2\/RBV<\/jats:styled-content> combination therapy is useful for treating IDU<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12066","type":"journal-article","created":{"date-parts":[[2013,3,28]],"date-time":"2013-03-28T02:47:18Z","timestamp":1364438838000},"page":"1013-1019","source":"Crossref","is-referenced-by-count":3,"title":["Combination therapy of natural human interferon\u2010beta and ribavirin for chronic hepatitis C<\/scp> patients with injection drug use"],"prefix":"10.1111","volume":"43","author":[{"given":"Hiroyasu","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Hepatology Graduate School of 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