{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T22:15:15Z","timestamp":1758406515296},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T00:00:00Z","timestamp":1361318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether spleen diffusion\u2010weighted imaging (<jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content>) parameters might classify liver fibrosis stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen miniature pigs were prospectively used to model liver fibrosis, and underwent spleen <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> by using b\u2009=\u2009300, 500 and 800\u2009s\/mm<jats:sup>2<\/jats:sup> on 0, 5th, 9th, 16th and 21st weekend after the beginning of modeling. Signal intensity ratio of spleen to paraspinous muscles (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>), spleen exponential apparent diffusion coefficient (e<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) and apparent diffusion coefficient (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>) for each b\u2010value were statistically analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With increasing stages of fibrosis, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> for all b\u2010values showed a downward trend; and spleen e<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> for b\u2009=\u2009300\u2009s\/mm<jats:sup>2<\/jats:sup> showed downward and upward trends, respectively (all <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009&lt;\u20090.05). The area under the receiver\u2013operator curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) of spleen <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> parameters was 0.777 or more by <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> for classifying each fibrosis stage, and 0.65 or more by e<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> and 0.648 or more by <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> for classifying stage \u22653 or cirrhosis. Among the spleen <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> parameters, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> for b\u2009=\u2009300\u2009s\/mm<jats:sup>2<\/jats:sup> was the best parameter in classifying stage 1 or more, 2 or more and 3 or more with <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of 0.875, 0.851 and 0.843, respectively; and spleen <jats:styled-content style=\"fixed-case\">eADC<\/jats:styled-content> for b\u2009=\u2009300\u2009s\/mm<jats:sup>2<\/jats:sup> was best in classifying stage 4 with an <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> of 0.988.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spleen <jats:styled-content style=\"fixed-case\">DWI<\/jats:styled-content> may be used to stage liver fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12076","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T14:22:54Z","timestamp":1359123774000},"page":"1231-1240","source":"Crossref","is-referenced-by-count":3,"title":["Spleen magnetic resonance diffusion\u2010weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study"],"prefix":"10.1111","volume":"43","author":[{"given":"Xiao\u2010li","family":"Chen","sequence":"first","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging Department of Radiology Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010wu","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Key Laboratory of Medical Imaging Department of Radiology Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan China"},{"name":"Department of Radiology Wayne 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