{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T22:51:17Z","timestamp":1789858277422,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to evaluate the performance of transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) for the assessment of liver fibrosis in chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) patients with beta\u2010thalassemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010six <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> patients with beta\u2010thalassemia underwent <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>, liver biopsy, <jats:styled-content style=\"fixed-case\">T<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010weighted magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) for the assessment of liver iron content (<jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>) and laboratory evaluation. The accuracy of <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and its correlation with the other variables was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> values increased proportional to fibrosis stage (<jats:italic>r<\/jats:italic>\u2009=\u20090.404, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), but was independent of <jats:styled-content style=\"fixed-case\">T<jats:sub>2<\/jats:sub><\/jats:styled-content>\u2010weighted <jats:styled-content style=\"fixed-case\">MRI\u2010LIC<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u2009=\u20090.064, <jats:italic>P<\/jats:italic>\u2009=\u20090.581). In multivariate analysis, fibrosis stage was still associated with the log\u2010transformed <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> score(standardized \u03b2\u2009=\u20090.42 for <jats:styled-content style=\"fixed-case\">F4<\/jats:styled-content> stage of <jats:styled-content style=\"fixed-case\">METAVIR<\/jats:styled-content>, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). No correlation was noted between <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> score (standardized \u03b2\u2009=\u20090.064, <jats:italic>P<\/jats:italic>\u2009=\u20090.512). The area under the receiver operating characteristic curve for prediction of cirrhosis was 80% (95% confidence interval, 59\u2013100%). A cut\u2010off <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> score of 11 had a sensitivity of 78% and specificity of 88.1% for diagnosing cirrhosis. The best cut\u2010off values for \u201c<jats:styled-content style=\"fixed-case\">TE\u2010FIB<\/jats:styled-content>\u20104 cirrhosis score\u201d comprising <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 and \u201c<jats:styled-content style=\"fixed-case\">TE\u2010APRI<\/jats:styled-content> cirrhosis score\u201d combining <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> with aspartate aminotransferase\u2010to\u2010platelet ratio index (<jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>) both had 87.5% sensitivity and 91.04% specificity for the diagnosis of cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regardless of <jats:styled-content style=\"fixed-case\">LIC<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> alone or when combined with <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 or <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>, is a diagnostic tool with moderate to high accuracy to evaluate liver fibrosis in <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> patients with beta\u2010thalassemia. However, because splenectomy in a proportion of our subjects might have affected the platelet count, the scores utilizing <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FIB<\/jats:styled-content>\u20104 should be interpreted cautiously.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12088","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T13:15:55Z","timestamp":1360242955000},"page":"1276-1283","source":"Crossref","is-referenced-by-count":21,"title":["Transient elastography in hepatitis <scp>C<\/scp> virus\u2010infected patients with beta\u2010thalassemia for assessment of fibrosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Hossein","family":"Poustchi","sequence":"first","affiliation":[{"name":"Digestive Diseases Research Institute Shariati Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoomeh","family":"Eslami","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Disease Research Center Firoozgar Hospital Tehran University Of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Ostovaneh","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Institute Shariati Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Modabbernia","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Institute Shariati Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Sima","family":"Saeedian","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Disease Research Center Firoozgar Hospital Tehran University Of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Institute Shariati Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"Storr Liver Unit Westmead Hospital University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Digestive Diseases Research Institute Shariati Hospital  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Zamani","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Disease Research Center Firoozgar Hospital Tehran University Of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07996.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20506"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00811.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.111302"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.135046"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.018"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069153"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21420"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.07.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.058"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.01011.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21752"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02662506"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3982"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.10.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15436-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240201"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310136"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21669"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.1.17"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.16602"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08412.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430503"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.04.002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.053"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21099"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.1.r99jl35227"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80070-5"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2007.12.021"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2009.00377.x"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:35:23Z","timestamp":1696343723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/hepr.12088"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12088","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,12]]}}}