{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:16:42Z","timestamp":1791393402798,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Aim<\/jats:title>Steatosis is a common histological feature of chronic liver disease, especially alcoholic and non\u2010alcoholic fatty liver disease, as well as chronic hepatitis C<\/jats:styled-content>. A recent study showed that evaluating the controlled attenuation parameter (CAP<\/jats:styled-content>) with transient elastography was an efficient way of non\u2010invasively determining the severity of hepatic steatosis. The objective of this study was to prospectively evaluate the utility of CAP<\/jats:styled-content> for diagnosing steatosis in patients with chronic liver disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and fifty\u2010five consecutive patients with suspected chronic liver disease underwent steatosis diagnosis using CAP<\/jats:styled-content>, blood sample analyses, computed tomography for assessing the liver\/spleen ratio and liver biopsy. Steatosis was graded according to the percentage of fat\u2010containing hepatocytes: S0<\/jats:styled-content>, less than 5%; S1<\/jats:styled-content>, 5\u201333%; S2<\/jats:styled-content>, 34\u201366%; and S3<\/jats:styled-content>: more than 66%.<\/jats:p><\/jats:sec>Results<\/jats:title>The CAP<\/jats:styled-content> was significantly correlated with steatosis grade, and there were significant differences between the CAP<\/jats:styled-content> value of the S0<\/jats:styled-content> patients and those of the patients with other grades of steatosis. S0<\/jats:styled-content> and S1<\/jats:styled-content>\u20133 hepatic steatosis were considered to represent mild and significant steatosis, respectively. The CAP<\/jats:styled-content> values of the patients with mild and significant steatosis were significantly different (P<\/jats:styled-content><\/jats:italic>\u2009<\u20090.0001). The area under the receiver\u2013operator curve (AUROC<\/jats:styled-content>) value of the CAP<\/jats:styled-content> for diagnosing significant steatosis was 0.878 (95% confidence interval, 0.818\u20130.939), and the optimal CAP<\/jats:styled-content> cut\u2010off value for detecting significant steatosis was 232.5\u2009db\/m. In multivariate analysis, the CAP<\/jats:styled-content> (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.0002) and the liver to spleen ratio (P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.004) were found to be significantly associated with significant steatosis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The CAP<\/jats:styled-content> is a promising tool for rapidly and non\u2010invasively diagnosing steatosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12094","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T10:29:01Z","timestamp":1364898541000},"page":"1182-1189","source":"Crossref","is-referenced-by-count":56,"title":["Utility of controlled attenuation parameter measurement for assessing liver steatosis in J<\/scp>apanese patients with chronic liver diseases"],"prefix":"10.1111","volume":"43","author":[{"given":"Keiichi","family":"Masaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism 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