{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T09:43:15Z","timestamp":1745746995501},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Hepatitis C<\/jats:styled-content> virus (HCV<\/jats:styled-content>) can affect immune cells and induce various kinds of immune\u2010related diseases including pyoderma gangrenosum. We experienced a difficult\u2010to\u2010treat case of pyoderma gangrenosum\u2010like lesions in a patient with HCV<\/jats:styled-content> infection. The patient was treated with pegylated interferon (PEG IFN<\/jats:styled-content>)\u2010\u03b1\u20102b and ribavirin (RBV<\/jats:styled-content>) therapy and achieved a sustained virological response. Before the eradication of HCV<\/jats:styled-content>, the frequency of T<\/jats:styled-content>\u2010helper 17<\/jats:styled-content> cells was remarkably high in comparison to chronic hepatitis C<\/jats:styled-content> patients without extrahepatic immune\u2010related diseases. Moreover, we could detect negative and positive strand\u2010specific HCV RNA<\/jats:styled-content> in the CD19<\/jats:styled-content>+<\/jats:sup> B<\/jats:styled-content> lymphocytes and CD4<\/jats:styled-content>+<\/jats:sup> T<\/jats:styled-content> lymphocytes. However, after the eradication of HCV<\/jats:styled-content>, the immunological status became normal and the pyoderma gangrenosum\u2010like lesions became stable without immunosuppressive therapy. Here, we report a sequential immunological analysis during PEG IFN<\/jats:styled-content>\/RBV<\/jats:styled-content> therapy and the beneficial effect of HCV<\/jats:styled-content> eradication in difficult\u2010to\u2010treat pyoderma gangrenosum\u2010like lesions.<\/jats:p>","DOI":"10.1111\/hepr.12102","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T04:12:51Z","timestamp":1362456771000},"page":"238-245","source":"Crossref","is-referenced-by-count":7,"title":["Eradication of hepatitis C<\/scp> virus could improve immunological status and pyoderma gangrenosum\u2010like lesions"],"prefix":"10.1111","volume":"44","author":[{"given":"Yasuteru","family":"Kondo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Tohoku University Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Iwata","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Tohoku University 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