{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:08:19Z","timestamp":1787440099887,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Dental infections are implicated in several systemic diseases due to bacteremia and pro\u2010inflammatory effects, but their possible role in liver disease is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical course of liver disease in relation to dental health among 116 patients with liver cirrhosis who underwent dental examination before liver transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The need for multiple tooth extractions, a surrogate marker of dental infections, was associated with reduced time from diagnosis of liver disease to the need for liver transplantation (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). The association was independent of age, sex, liver disease etiology and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odel for <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>nd\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tage <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease (<jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content>) score (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Among 38 patients with accurate laboratory follow\u2010up data, the number of tooth extractions correlated with the change in <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score during the year preceding dental examination (<jats:italic>r<\/jats:italic>\u2009=\u20090.43, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Spontaneous bacterial peritonitis caused by <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>treptococcus viridans<\/jats:italic> occurred only among patients with multiple dental infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dental infections may influence the clinical course of liver disease, but prospective studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12126","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T10:36:33Z","timestamp":1365158193000},"page":"349-353","source":"Crossref","is-referenced-by-count":55,"title":["Association between dental infections and the clinical course of chronic liver disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Fredrik","family":"\u00c5berg","sequence":"first","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Helenius\u2010Hietala","sequence":"additional","affiliation":[{"name":"Department of Oral Infectious Diseases Institute of Dentistry University of Helsinki  Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Meurman","sequence":"additional","affiliation":[{"name":"Department of Oral Infectious Diseases Institute of Dentistry University of Helsinki  Helsinki Finland"},{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Isoniemi","sequence":"additional","affiliation":[{"name":"Transplantation and Liver Surgery Clinic Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.10.002"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.07.011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080220"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425908095130"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2009.00122.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25915"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.048181"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0805786"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60002-6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-3-200308050-00008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070056"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-16"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.05.015"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00389-09"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200509000-00008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2004.0985.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01381.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.00011.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0738-1"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12126","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:47:39Z","timestamp":1696286859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,29]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/hepr.12126"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12126","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,29]]}}}