{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:41:29Z","timestamp":1782949289070,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the prevalence of autoantibodies against nucleosomes (anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content>) in patients with autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>), examine the correlation between anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> and disease activity, and evaluate the effectiveness of anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> in predicting relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed serum anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> levels in 38 patients with <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> by enzyme\u2010linked immunosorbent assay, and assessed their correlation with clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> levels were significantly higher in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>, but not in patients with chronic hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200920) or chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200920), compared to healthy controls (<jats:italic>n<\/jats:italic>\u2009=\u200915). The positive prevalence of anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> was 71.1% in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>. Anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> levels were significantly lower during remission compared to that during flares within the same patients with <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>. Total bilirubin levels were significantly higher in patients with anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> levels of 53.7\u2009<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\/mL or more compared to those with less than 53.7\u2009<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\/mL at disease onset. Analysis of the reduction in anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> by immunosuppressive therapy in 16 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients revealed that age at disease onset was significantly lower and <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> levels and relapse rates were significantly higher in patients with a reduction rate of less than 35% compared to those with a reduction rate 35% or more. The <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>utoimmune <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>epatitis <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup score and \u03b3\u2010globulin levels were also higher in patients with reduction rates of less than 35% (borderline significance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010nucleosome <jats:styled-content style=\"fixed-case\">Ab<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients may be useful markers not only for disease diagnosis, but also for activity assessment and relapse prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12130","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T09:35:27Z","timestamp":1365413727000},"page":"420-428","source":"Crossref","is-referenced-by-count":11,"title":["Anti\u2010nucleosome autoantibodies as markers for autoimmune hepatitis and their correlation with disease activity"],"prefix":"10.1111","volume":"44","author":[{"given":"Junko","family":"Yokokawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima 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