{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:09:07Z","timestamp":1773288547587,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>A 67\u2010year\u2010old male living in<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>su city,<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ie prefecture,<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan was referred to our hospital for further examination of acute liver injury and was diagnosed as having clinical hepatitis<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) infection in<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2010. The<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>strain (<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">JA11<\/jats:styled-content>\u20101701) isolated from the patient belonged to genotype 3 and European\u2010type subgenotype 3e. It was presumed that the patient had been infected from a wild boar (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content><jats:italic>us scrofa leucomystax<\/jats:italic>) because he consumed meat\/viscera from a wild boar that he had captured himself as a hunter approximately 2 months before disease onset. A specimen of the boar meat\/viscera that the patient had ingested was not available. However, the<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">JA11<\/jats:styled-content>\u20101701 strain was 99.8% identical within the 412\u2010nucleotide sequence of the open reading frame 2 region to a<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>strain (<jats:styled-content style=\"fixed-case\">JBOAR012\u2010Mie08<\/jats:styled-content>) that had been recovered from a wild boar captured near the patient's hunting area in 2008. A phylogenetic analysis confirmed that the two<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>strains had a close genetic relationship and were segregated into subgenotype 3e, supported by a high bootstrap value of 99%. Of note, the<jats:styled-content style=\"fixed-case\">HE<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">JA11<\/jats:styled-content>\u20101701 and<jats:styled-content style=\"fixed-case\">JBOAR012<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">Mie08<\/jats:styled-content>strains were remotely related to the 3e strains reported in<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan and European countries, with a nucleotide difference of 7.9\u201313.9%, reinforcing the uniqueness of the 3e strains obtained in the present study. These results strongly support our speculation that the patient developed acute hepatitis<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>via consumption of<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010infected boar meat\/viscera. Genetic analyses of<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>strains are useful for tracing infectious sources in sporadic cases of acute hepatitis<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hepr.12155","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T20:23:35Z","timestamp":1367526215000},"page":"694-699","source":"Crossref","is-referenced-by-count":17,"title":["High genomic similarity between<scp>E<\/scp>uropean type hepatitis<scp>E<\/scp>virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in<scp>M<\/scp>ie,<scp>J<\/scp>apan"],"prefix":"10.1111","volume":"44","author":[{"given":"Hiroshi","family":"Okano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Suzuka General Hospital Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsunori","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fujita Health University Nanakuri Sanatorium Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Mie University School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Toshiba General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Toshiba General Hospital Tokyo Japan"},{"name":"Department of Gastroenterology Toshiba General Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology Department of Infection and Immunity Jichi Medical University School of Medicine Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp048285"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1017"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6088"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.47.384"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.9.3209-3218.2002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.1065"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03300.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20215"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.02.002"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19242-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19052-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5371-5374.2004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-011-0988-x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1112.051041"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/378074"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.47.465"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.47.459"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.47.316"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.47.161"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.51.418"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.52.524"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18918-0"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.482"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.1.49-56.2005"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81912-0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2957\/kanzo.52.295"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2012.06.002"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02728.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80316-5"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.01.008"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2003.12.026"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-011-1153-2"},{"key":"e_1_2_5_35_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7883\/yoken.JJID.2006.136","article-title":"A diffuse outbreak of hepatitis E in Mie Prefecture, 2005","volume":"59","author":"Nakano Y","year":"2006","journal-title":"Jpn J Infect Dis"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12155","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:31:38Z","timestamp":1715301098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,27]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/hepr.12155"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12155","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,27]]}}}