{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:23:24Z","timestamp":1760865804439},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the recurrence and survivals between hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) with major portal vein tumor thrombus (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) and major hepatic vein <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> after hepatic resection (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was carried out with the medical records of 272 patients who underwent hepatic resection and thrombectomy for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> with major portal vein (group A) or hepatic vein (group B) <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>. The clinicopathological parameters, recurrence, survivals and prognostic significance associated with major portal or hepatic vein <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in group A had a better median survival compared with their counterparts in group B (52 vs 38 weeks; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). One\u2010, 2\u2010 and 3\u2010year survival rates were markedly greater in group A than in group B (50% vs 38.8%, 26% vs 15.9% and 11.4% vs 6.1%, respectively). There was no statistical difference in recurrence\u2010free survival rate but extrahepatic recurrences were more often seen in group B. In multivariate analysis, <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> location (hepatic veins vs portal veins), type of resection (anatomical vs non\u2010anatomical) and liver cirrhosis (none\/mild vs moderate\/severe) were significant prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and major hepatic vein <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> had higher incidence of extrahepatic metastases and worse overall survival after hepatic resection compared with patients with major portal vein <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>. With preserved liver function, patients can receive aggressive treatments and survivals could be prolonged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12185","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T11:45:04Z","timestamp":1371210304000},"page":"761-768","source":"Crossref","is-referenced-by-count":14,"title":["Recurrence and survivals following hepatic resection for hepatocellular carcinoma with major portal\/hepatic vein tumor thrombus"],"prefix":"10.1111","volume":"44","author":[{"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery West China Hospital Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Surgery West China Hospital Sichuan University  Chengdu 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