{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:08:39Z","timestamp":1761919719108},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Aim<\/jats:title>To compare the clinical outcome of patients undergoing liver resection under ischemic preconditioning (IP<\/jats:styled-content>) versus intermittent clamping (IC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A systematic published work search was conducted to detect randomized controlled trials (RCT<\/jats:styled-content>) comparing IP<\/jats:styled-content> and intermittent clamping of the portal triad. A meta\u2010analysis was conducted to estimate postoperative morbidity and mortality, blood loss, transfusion requirement, and liver injury based on the levels of bilirubin, aspartate aminotransferase (AST<\/jats:styled-content>) and alanine aminotransferase (ALT<\/jats:styled-content>). Meta\u2010analysis was performed using either the fixed\u2010effects model or random\u2010effects model.<\/jats:p><\/jats:sec>Results<\/jats:title>Five RCT<\/jats:styled-content> published between 2006 and 2012 containing a total of 403 patients were eligible for final analysis. Meta\u2010analysis of operative time showed it was lower in the IP<\/jats:styled-content> group than the IC<\/jats:styled-content> group with weighted mean difference (WMD<\/jats:styled-content>) of \u221218.23 (95% confidence interval (CI<\/jats:styled-content>), \u221228.58 to \u22127.87; P<\/jats:italic>\u2009=\u20090.0006). Meta\u2010analysis of ALT<\/jats:styled-content> levels indicated lower levels in the IP<\/jats:styled-content> group on postoperative days 3 and 7 (WMD<\/jats:styled-content> on day 3: \u201345.27, 95% CI<\/jats:styled-content>, \u221249.92 to \u221240.62; P<\/jats:italic>\u2009<\u20090.00001; I2<\/jats:sup>\u2009=\u20090%; WMD<\/jats:styled-content> on day 7: \u201324.33, 95% CI<\/jats:styled-content>, \u221228.04 to \u221220.62; P<\/jats:italic>\u2009<\u20090.00001; I2<\/jats:sup>\u2009=\u20090%). Meta\u2010analyses revealed no significant difference in blood loss, transfusion requirement, mortality, morbidity, ischemic duration, hospital stay, AST<\/jats:styled-content> and bilirubin levels on postoperative days 1, 3 and 7, and ALT<\/jats:styled-content> levels on postoperative day 1 between IP<\/jats:styled-content> and IC<\/jats:styled-content> groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>On currently available evidence, IP<\/jats:styled-content> does not offer a satisfying benefit to patients undergoing hepatic resection. However, they have lower operative time and less liver injury after liver resections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12193","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T14:15:33Z","timestamp":1372774533000},"page":"878-887","source":"Crossref","is-referenced-by-count":6,"title":["Ischemic preconditioning versus intermittent clamping of portal triad in liver resection: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"44","author":[{"given":"Ying","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 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Medical College Xi'an Jiaotong University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an 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