{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:53:07Z","timestamp":1761663187955},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Aim<\/jats:title>The objective of the current study was to find baseline predictive factors of response to therapy with pegylated interferon and ribavirin (PEG\u2010IFN<\/jats:styled-content>\/RBV<\/jats:styled-content> therapy) in children and adolescents with chronic hepatitis C<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>IL28B<\/jats:italic><\/jats:styled-content> genotype and mutations in the core of hepatitis C virus (HCV)<\/jats:styled-content> were analyzed in 30 patients treated with PEG\u2010IFN<\/jats:styled-content>\/RBV<\/jats:styled-content> for HCV<\/jats:styled-content> infection. The initial rate of decrease in the viral load was assessed during the first 2 weeks of treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>IL28B<\/jats:italic><\/jats:styled-content> major allele was seen more frequently in patients with sustained virologic response (SVR<\/jats:styled-content>) than in non\u2010SVR<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.001). There was no difference between these two groups in frequency of C<\/jats:styled-content>ore 70 mutation. Among patients with genotype\u20101, SVR<\/jats:styled-content> was achieved in more patients (P<\/jats:italic>\u2009=\u20090.007) in the IL28B<\/jats:italic><\/jats:styled-content> major allele group than in those in the minor allele group. The early decrements in the viral load (log\/2 weeks) were 3.80\u2009\u00b1\u20090.86 in the genotype\u20102 major allele group, 1.82\u2009\u00b1\u20090.84 in the genotype\u20101 major allele group, and 0.41\u2009\u00b1\u20090.33 in the genotype\u20101 minor allele group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Among pediatric patients with HCV<\/jats:styled-content> infection the effectiveness of PEG\u2010IFN<\/jats:styled-content>\/RBV<\/jats:styled-content> therapy may be lower in the group with genotype\u20101 IL28B<\/jats:italic><\/jats:styled-content> minor alleles than in other groups with IL28B<\/jats:italic><\/jats:styled-content> major allele. Treatment strategy should be carefully implemented in patients with IL28B<\/jats:italic><\/jats:styled-content> unfavorable type.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12206","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T11:01:49Z","timestamp":1373540509000},"source":"Crossref","is-referenced-by-count":9,"title":["Association of IL28B<\/i><\/scp> polymorphisms with virological response to peginterferon and ribavirin therapy in children and adolescents with chronic hepatitis C<\/scp>"],"prefix":"10.1111","volume":"44","author":[{"given":"Hitoshi","family":"Tajiri","sequence":"first","affiliation":[{"name":"Department of Pediatrics Osaka General Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka General Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Juntendo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Abukawa","sequence":"additional","affiliation":[{"name":"Miyagi Children's Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka University, Graduate School of Medicine Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics 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