{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:30:10Z","timestamp":1726759810786},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Aim<\/jats:title>We analyzed the characteristics of alanine aminotransferase (ALT<\/jats:styled-content>) abnormality after achieving hepatitis B<\/jats:styled-content> e\u2010antigen (HBeAg<\/jats:styled-content>) seroconversion (SC<\/jats:styled-content>) and other factors associated with the occurrence of HBeAg<\/jats:styled-content> negative hepatitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>We followed 36 patients with chronic hepatitis B<\/jats:styled-content> from 3 years prior to at least 3 years after SC<\/jats:styled-content> (mean, 11.6 years) and examined ALT<\/jats:styled-content>, hepatitis B<\/jats:styled-content> virus (HBV<\/jats:styled-content>) DNA<\/jats:styled-content>, HB<\/jats:styled-content> surface antigen, HB<\/jats:styled-content> core\u2010related antigen (HBcrAg<\/jats:styled-content>) levels and mutations related to HBeAg SC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>ALT<\/jats:styled-content> normalization (<31\u2009IU\/L<\/jats:styled-content> for at least 1 year) was primarily observed until 2 years following SC<\/jats:styled-content>, after which it became more infrequent. We next divided patients into abnormal (\u226531\u2009IU\/L<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200920) and normal (<31\u2009IU\/L<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200916) groups based on integrated ALT<\/jats:styled-content> level after the time point of 2 years from SC<\/jats:styled-content>, and considered the former group as having HBeAg<\/jats:styled-content> negative hepatitis in the present study. Although changes in median levels of ALT<\/jats:styled-content> and HBcrAg<\/jats:styled-content> differed significantly between the groups, multivariate analysis showed ALT<\/jats:styled-content> normalization within 2 years after SC<\/jats:styled-content> to be the only significant determining factor for this disease (P<\/jats:italic>\u2009=\u20090.001). We then assessed the 19 patients whose ALT<\/jats:styled-content> was normal at 2 years following SC<\/jats:styled-content>, four of whom developed HBeAg<\/jats:styled-content> negative hepatitis. Increased levels of HBV DNA<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.037) and HBcrAg<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.033) were significant factors of potential relevance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>ALT<\/jats:styled-content> abnormality after 2 years of SC<\/jats:styled-content> may be evaluated as HBeAg<\/jats:styled-content>\u2010negative hepatitis. ALT<\/jats:styled-content>, HBV DNA<\/jats:styled-content> and HBcrAg<\/jats:styled-content> levels may be useful in predicting the outcome of patients who achieve HBeAg SC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12208","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T08:48:40Z","timestamp":1373964520000},"source":"Crossref","is-referenced-by-count":3,"title":["Characteristics and prediction of hepatitis B<\/scp> e\u2010antigen negative hepatitis following seroconversion in patients with chronic hepatitis B<\/scp>"],"prefix":"10.1111","volume":"44","author":[{"given":"Susumu","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Medicine Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Medicine Shinshu University School of Medicine Matsumoto 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