{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:28:17Z","timestamp":1787498897765,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"\n Aim<\/jats:title>\n \n Minimal hepatic encephalopathy (\n MHE<\/jats:styled-content>\n ) affects more than 30% of patients with cirrhosis, and it has been suggested that despite no recognizable clinical symptoms of neurological abnormalities, it may affect health\u2010related quality of life (\n HRQL<\/jats:styled-content>\n ); however, this fact remains controversial. The aim of our study was to evaluate the prevalence of\n MHE<\/jats:styled-content>\n and\n HRQL<\/jats:styled-content>\n in patients diagnosed with decompensated cirrhosis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with liver cirrhosis were selected independent of the etiology of the disease. All patients underwent a complete clinical history, and only patients with decompensated hepatic cirrhosis were included. Psychometric tests were applied to evaluate the presence of\n MHE<\/jats:styled-content>\n along with the\n C<\/jats:styled-content>\n hronic\n L<\/jats:styled-content>\n iver\n D<\/jats:styled-content>\n isease\n Q<\/jats:styled-content>\n uestionnaire. Appetite was measured by verbal and visual analog scales.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and twenty\u2010five patients were included with a median age of 56.0 years. They were classified according to the\n C<\/jats:styled-content>\n hild\u2013\n P<\/jats:styled-content>\n ugh index as\n A<\/jats:styled-content>\n , (\n n<\/jats:italic>\n \u2009=\u200956),\n B<\/jats:styled-content>\n , (\n n<\/jats:italic>\n \u2009=\u200951) and\n C<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u200918). Prevalence of\n MHE<\/jats:styled-content>\n was 44.0% (\n n<\/jats:italic>\n \u2009=\u200955). In patients with\n MHE<\/jats:styled-content>\n , a significant reduction was observed in domains of activity (3.3 [2.0] vs 4.8 [2.8]), fatigue (3.2 [2.0] vs 3.9 [2.3]), systemic symptoms (3.8 [2.0] vs 4.8 [1.7]), emotional function (3.6 [1.9] vs 4.0 [1.9]) and global scoring (3.7 [1.7] vs 4.3 [1.8]) when compared with non\u2010\n MHE<\/jats:styled-content>\n patients (\n n<\/jats:italic>\n \u2009=\u200970). Twenty\u2010two percent of the patients with\n MHE<\/jats:styled-content>\n reported little appetite compared with 11% in the non\u2010\n MHE<\/jats:styled-content>\n group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The results suggest that\n MHE<\/jats:styled-content>\n and a reduction in appetite are associated with deterioration in\n HRQL<\/jats:styled-content>\n in patients with decompensated cirrhosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hepr.12227","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T06:43:34Z","timestamp":1376894614000},"source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of minimal hepatic encephalopathy and quality of life in patients with decompensated cirrhosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Aline","family":"Mina","sequence":"first","affiliation":[{"name":"Laboratory of Gastro\u2010hepatology Research Hospital de Pediatr\u00eda and Gastroenterology Department CMN Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segundo","family":"Moran","sequence":"additional","affiliation":[{"name":"Laboratory of Gastro\u2010hepatology Research Hospital de Pediatr\u00eda and Gastroenterology Department CMN Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayeli","family":"Ortiz\u2010Olvera","sequence":"additional","affiliation":[{"name":"Laboratory of Gastro\u2010hepatology Research Hospital de Pediatr\u00eda and Gastroenterology Department CMN Siglo XXI Mexican Institute of Social Security Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertino","family":"Mera","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville Tennessee 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