{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:07:26Z","timestamp":1760267246938},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Aim<\/jats:title>To reveal the site of immunoglobulin (Ig<\/jats:styled-content>)M<\/jats:styled-content> production in primary biliary cirrhosis (PBC<\/jats:styled-content>) we performed immunohistochemical analysis on spleens collected from patients with PBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Splenic tissue samples were collected at the time of the autopsy from patients with hepatic failure. Immunostaining for IgM<\/jats:styled-content>, CD21<\/jats:styled-content> and CXCL13<\/jats:styled-content> were performed using the splenic tissue samples.<\/jats:p><\/jats:sec>Results<\/jats:title>The samples from five out of eight cases with PBC<\/jats:styled-content> but not in eight cases of chronic hepatitis C<\/jats:styled-content> virus infection showed accumulation of IgM<\/jats:styled-content> positive cells in CD21<\/jats:styled-content> positive lymph follicles. The CXCL13<\/jats:styled-content> positive cells also accumulated in the center of the lymph follicles where the IgM<\/jats:styled-content> positive cells accumulated.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The present results suggest that excess IgM<\/jats:styled-content> is produced from the spleen of PBC<\/jats:styled-content>. Furthermore, it was suggested that CXCL13<\/jats:styled-content> positive follicular dendritic cells possibly contribute to this process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12231","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T12:12:30Z","timestamp":1377778350000},"source":"Crossref","is-referenced-by-count":8,"title":["Splenic lymph follicles generate immunoglobulin M<\/scp>\u2010producing B<\/scp> cells in primary biliary cirrhosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Kentaro","family":"Kikuchi","sequence":"first","affiliation":[{"name":"The Fourth Department of Internal Medicine Teikyo University Mizonokuchi Hospital Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Graduate School of Medicine and Pharmaceutical Science University of Toyama Toyama 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