{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:39:07Z","timestamp":1772973547581,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Aim<\/jats:title>Evaluate efficacy\/safety of oral l\u2010ornithine\u2010l\u2010aspartate (LOLA<\/jats:styled-content>) in controlling minimal hepatic encephalopathy (MHE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Consecutive cirrhotic outpatients with MHE<\/jats:styled-content> (defined by psychometric number connection tests A<\/jats:styled-content>\/B<\/jats:styled-content> [NCT<\/jats:styled-content>\u2010A<\/jats:styled-content>\/B<\/jats:styled-content>] and digit symbol substitution test [DSST<\/jats:styled-content>] score of >2 standard deviations) were randomized to a 60\u2010day oral LOLA<\/jats:styled-content> (5\u2009g t.i.d) or placebo group. Critical flicker frequency test (CFF<\/jats:styled-content>), quantitative electroencephalogram (qEEG<\/jats:styled-content>), arterial ammonia (NH3<\/jats:styled-content>), B<\/jats:styled-content>eck's anxiety\u2013depression forms and liver disease quality of life (LD\u2010QOL<\/jats:styled-content>) were assessed. Patients were followed for 6\u2009months after the end of the study to assess LOLA<\/jats:styled-content> prophylactic role on overt hepatic encephalopathy (OHE<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Sixty\u2010four patients were included, 63 (98.4%) with MHE<\/jats:styled-content>. In six of these patients, CFT<\/jats:styled-content> was less than 39\u2009Hz (9.52%); NH3<\/jats:styled-content> was increased in 32 (50.8%); 25% had abnormal qEEG<\/jats:styled-content>. Age, sex, scholarship, C<\/jats:styled-content>hild\u2013P<\/jats:styled-content>ugh (CP<\/jats:styled-content>), M<\/jats:styled-content>odel for E<\/jats:styled-content>nd\u2010S<\/jats:styled-content>tage L<\/jats:styled-content>iver D<\/jats:styled-content>isease, NCT<\/jats:styled-content>\u2010A<\/jats:styled-content>\/B<\/jats:styled-content>, DSST<\/jats:styled-content>, CFF<\/jats:styled-content> and NH3<\/jats:styled-content> were similar in both groups at the baseline. LOLA<\/jats:styled-content> led to a significant improvement in NCT<\/jats:styled-content>\u2010B<\/jats:styled-content> age\u2010controlled z\u2010score (3.4\u2009\u00b1\u20093.4 vs 1.5\u2009\u00b1\u20092.3, P<\/jats:italic>\u2009=\u20090.01) and CFF<\/jats:styled-content> (42.2\u2009\u00b1\u20095.8 vs 45.2\u2009\u00b1\u20095.8, P<\/jats:italic>\u2009=\u20090.02), comparing the first and the last visit, but there were no differences between LOLA<\/jats:styled-content> and placebo regarding the whole psychometric battery, CFF<\/jats:styled-content>, LD\u2010QOL<\/jats:styled-content> and B<\/jats:styled-content>eck's forms. No serious adverse effects occurred. Patients taking LOLA<\/jats:styled-content> had less episodes of OHE<\/jats:styled-content> at 6\u2009months (5% vs 37.9%, P<\/jats:italic>\u2009=\u20090.016), as they have significant improvement on liver function assessed by CP<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A 60\u2010day oral LOLA<\/jats:styled-content> course was not better than placebo in treating MHE<\/jats:styled-content>, but was useful in preventing further episodes of OHE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12235","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T12:37:02Z","timestamp":1378211822000},"page":"956-963","source":"Crossref","is-referenced-by-count":47,"title":["Oral l\u2010ornithine\u2010l\u2010aspartate in minimal hepatic encephalopathy: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"44","author":[{"given":"Mario 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