{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:11:47Z","timestamp":1696399907844},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Erythropoietin is widely used in the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> and some other <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern countries to maintain doses of ribavirin during peginterferon\/ribavirin\u2010based treatment for chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection. However, the impact of erythropoietin on sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) is unclear. Here, we report the cases of three Japanese ribavirin\u2010intolerant relapsed patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 2 who achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> from retreatment by adding erythropoietin. Three women aged 50, 64 and 68 years with chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 2 received retreatment with peginterferon\u2010\u03b1 and ribavirin. During their prior therapy, <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> became negative according to real\u2010time polymerase chain reaction at weeks 4\u20138 in all three patients; however, the total dose of ribavirin was 18.1\u201330.6% lower than the planned dose, and <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> relapsed post\u2010treatment. At present, epoetin\u2010\u03b2 24\u2009000\u2009<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> was introduced at weeks 2 or 3 of dual\u2010combination therapy, resulting in a less than 4.2% reduction in the total dose of ribavirin. <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content> became negative at weeks 4\u20138, and all patients achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>. Until the next\u2010generation antiviral treatments for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 2 become available, the addition of erythropoietin to dual therapy can be a treatment of choice for ribavirin\u2010intolerant relapsed patients.<\/jats:p>","DOI":"10.1111\/hepr.12257","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:26:23Z","timestamp":1381749983000},"source":"Crossref","is-referenced-by-count":1,"title":["Adjuvant epoetin\u2010\u03b2 with peginterferon\u2010\u03b1 and ribavirin in <scp>J<\/scp>apanese ribavirin\u2010intolerant relapsed patients with chronic hepatitis <scp>C<\/scp> genotype 2"],"prefix":"10.1111","volume":"44","author":[{"given":"Masaru","family":"Enomoto","sequence":"first","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tamori","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka City University Graduate School of Medicine  Osaka 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