{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:41:07Z","timestamp":1696311667609},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Aim<\/jats:title>The clinical presentation of P<\/jats:styled-content>rimary biliary cirrhosis (PBC<\/jats:styled-content>) at the time of liver transplantation (LT<\/jats:styled-content>) may have changed, due to the long\u2010term use of ursodeoxycholic acid (UDCA<\/jats:styled-content>). The aim of this retrospective study was to investigate whether the clinical characteristics of LT<\/jats:styled-content> recipients with PBC<\/jats:styled-content> have changed over the years.<\/jats:p><\/jats:sec>Methods<\/jats:title>Of all 421 adults undergoing LT<\/jats:styled-content> from 1997 to 2012 at our center, we included 85 recipients with PBC<\/jats:styled-content> into the present study. The 85 recipients were divided into three groups according to the year LT<\/jats:styled-content> was performed: group 1 (1997\u20132001, n<\/jats:italic>\u2009=\u200929), group 2 (2002\u20132005, n<\/jats:italic>\u2009=\u200929) and group 3 (2006\u20132012, n<\/jats:italic>\u2009=\u200927).<\/jats:p><\/jats:sec>Results<\/jats:title>There were no significant differences in sex, recipient age, Model for End\u2010Stage Liver Disease score, updated Mayo risk score for PBC<\/jats:styled-content>, or liver\u2010related complications except for esophageal varices among the three groups. Patients in group 1 were complicated with esophageal varices less frequently than those in the other two groups. In older cases, the ratio of explanted liver volume to standard liver volume (ELV<\/jats:styled-content>\/SLV<\/jats:styled-content>) was significantly higher, and the duration of pre\u2010LT UDCA<\/jats:styled-content> treatment was significantly shorter. The duration of UDCA<\/jats:styled-content> treatment was significantly correlated with ELV<\/jats:styled-content>\/SLV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Recent LT<\/jats:styled-content> patients were characterized by more frequent portal hypertension and more severe liver atrophy, with longer UDCA<\/jats:styled-content> therapy prior to LT<\/jats:styled-content>, which might have prevented the somewhat rapid progression of liver failure characterized by hepatomegaly with insignificant fibrosis or portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12283","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T02:15:18Z","timestamp":1386036918000},"page":"993-999","source":"Crossref","is-referenced-by-count":1,"title":["Chronologic changes of explanted liver volume and the use of ursodeoxycholic acid in patients with end\u2010stage primary biliary 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hepatology Nagasaki University Graduate School of Biomedical Sciences Clinical Research Center National Hospital Organization Nagasaki Medical Center Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"The Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Aoki","sequence":"additional","affiliation":[{"name":"The Artificial Organ and Transplantation Division Department of Surgery Graduate School of Medicine The University of Tokyo Tokyo 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