{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:15:25Z","timestamp":1790738125948,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Aim<\/jats:title>Recently, serum levels of anti\u2010programmed cell death\u20101 (anti\u2010PD<\/jats:styled-content>\u20101) antibodies have been reported to be useful for the discrimination of type 1 autoimmune hepatitis (AIH<\/jats:styled-content>) from drug\u2010induced liver injury (DILI<\/jats:styled-content>) and to be associated with clinical features of type 1 AIH<\/jats:styled-content>. This multicenter study aimed to validate the usefulness of serum anti\u2010PD<\/jats:styled-content>\u20101 antibody as a serological marker for type 1 AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Serum samples before the initiation of corticosteroid treatment were obtained from 71 type 1 AIH<\/jats:styled-content> patients and 37 DILI<\/jats:styled-content> patients. Serum levels of anti\u2010PD<\/jats:styled-content>\u20101 antibodies were measured by indirect enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec>Results<\/jats:title>Serum levels of anti\u2010PD<\/jats:styled-content>\u20101 antibodies were higher in type 1 AIH<\/jats:styled-content> patients than in DILI<\/jats:styled-content> patients (P<\/jats:italic>\u2009<\u20090.001). The receiver\u2013operator curve analysis showed that serum levels of anti\u2010PD<\/jats:styled-content>\u20101 antibodies were useful for the discrimination of type 1 AIH<\/jats:styled-content> from DILI<\/jats:styled-content> (area under the curve, 0.80). On the other hand, the multivariate C<\/jats:styled-content>ox proportional hazard model showed that positivity for serum anti\u2010PD<\/jats:styled-content>\u20101 antibody, probable diagnosis based on the revised scoring system proposed by the I<\/jats:styled-content>nternational A<\/jats:styled-content>utoimmune H<\/jats:styled-content>epatitis G<\/jats:styled-content>roup, and prothrombin activity of less than 60% were associated with the later normalization of serum transaminase levels. During the clinical course, the disease relapsed more frequently in patients positive for serum anti\u2010PD<\/jats:styled-content>\u20101 antibody (36% vs 11%).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study suggests that serum anti\u2010PD<\/jats:styled-content>\u20101 antibody is useful for the diagnosis of type 1 AIH<\/jats:styled-content> as an auxiliary diagnostic marker, and that serum levels of anti\u2010PD<\/jats:styled-content>\u20101 antibodies reflect clinical features of type 1 AIH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12305","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T02:14:40Z","timestamp":1391825680000},"page":"1299-1307","source":"Crossref","is-referenced-by-count":18,"title":["Multicenter validation study of anti\u2010programmed cell death\u20101 antibody as a serological marker for type 1 autoimmune hepatitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Yasuhiro","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Ehime"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Ehime"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama 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