{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T06:42:49Z","timestamp":1696401769609},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Peginterferon (<jats:styled-content style=\"fixed-case\">PEG IFN<\/jats:styled-content>) and ribavirin combination therapy is a curative treatment for chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection, and virological response to <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> therapy has been strongly associated with genetic variation in <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><\/jats:italic> single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>). Recently, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>122 (mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122), which is the most abundant mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in the liver, has been reported to be important for the replication of <jats:styled-content style=\"fixed-case\">HCV RNA<\/jats:styled-content>. Therefore, we investigated the correlation of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 expression with virological response to <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> and other clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 51 patients with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection who were treated with <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> therapy at <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>agasaki <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital from 2006 to 2011 were included in this study. We investigated the correlation of mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 expression in liver biopsy specimens with virological response to <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> therapy and other predictors of response, including <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 expression did not correlate with <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>28 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>. However, a significant difference was observed in mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 expression between patients who showed a sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) and those who did not (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate analysis indicated that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 is an independent predictor of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010122 expression could be a marker for predicting the outcome of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> therapy. Therapies targeting miR\u2010122 may have positive effects not only by directly inhibiting viral propagation but also by ameliorating cholesterol and lipid abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12317","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T05:22:36Z","timestamp":1393305756000},"page":"88-96","source":"Crossref","is-referenced-by-count":11,"title":["Significance of mi<scp>RNA<\/scp>\u2010122 in chronic hepatitis <scp>C<\/scp> patients with serotype 1 on interferon therapy"],"prefix":"10.1111","volume":"45","author":[{"given":"Yasuhiro","family":"Kamo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of 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