{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:03:55Z","timestamp":1748966635103},"reference-count":39,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Aim<\/jats:title>Increased serum \u03b1\u2010fetoprotein (AFP<\/jats:styled-content>) has been associated with a good prognosis following acute liver failure (ALF<\/jats:styled-content>), but the levels of the fucosylated fraction of AFP<\/jats:styled-content> (Lens culinaris<\/jats:italic> agglutinin\u2010reactive fraction of AFP [AFP\u2010L3<\/jats:styled-content>]) following acute liver injury remain unknown. The aim of the present study was to investigate the clinical significance of AFP<\/jats:styled-content> and AFP\u2010L3<\/jats:styled-content> in patients with acute liver injury.<\/jats:p><\/jats:sec>Methods<\/jats:title>We investigated the serum levels of AFP<\/jats:styled-content> and highly sensitive AFP\u2010L<\/jats:styled-content>3% in 27 patients with acute\u2010onset autoimmune hepatitis (AIH<\/jats:styled-content>), 28 patients with acute hepatitis (AH<\/jats:styled-content>) and 22 patients with ALF<\/jats:styled-content> at the onset using a highly sensitive immunoassay (micro\u2010total analysis system).<\/jats:p><\/jats:sec>Results<\/jats:title>The serum AFP<\/jats:styled-content> levels were increased in patients with AIH<\/jats:styled-content>, AH<\/jats:styled-content> and ALF<\/jats:styled-content>, but the levels did not significantly differ among them. However, the mean AFP\u2010L<\/jats:styled-content>3% level was significantly higher in patients with AIH<\/jats:styled-content> than in patients with AH<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.0039). Moreover, significantly more patients with AIH<\/jats:styled-content> demonstrated AFP\u2010L<\/jats:styled-content>3 positivity (\u226510%) when compared with patients with AH<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.014). Although the percentage of AFP<\/jats:styled-content>\u2010L3 positivity increased with AFP<\/jats:styled-content> levels, at low serum AFP<\/jats:styled-content> levels (<10\u2009ng\/mL), significantly more patients with AIH<\/jats:styled-content> demonstrated AFP<\/jats:styled-content>\u2010L3 positivity than did patients with AH<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.024) or ALF<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.038).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We demonstrated for the first time that highly sensitive AFP\u2010L<\/jats:styled-content>3% levels were increased at the onset of AIH<\/jats:styled-content>. The mechanism underlying the increase in AFP\u2010L<\/jats:styled-content>3 remains to be elucidated, but this finding may reflect an alteration of the glycosylation such as hyperfucosylation, which can influence the modifications of self\u2010antigens in hepatocytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12318","type":"journal-article","created":{"date-parts":[[2014,2,25]],"date-time":"2014-02-25T08:06:40Z","timestamp":1393315600000},"source":"Crossref","is-referenced-by-count":4,"title":["Increase of fucosylated alpha\u2010fetoprotein fraction at the onset of autoimmune hepatitis and acute liver failure"],"prefix":"10.1111","volume":"44","author":[{"given":"Satoshi","family":"Yamagiwa","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Niigata 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