{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:37:40Z","timestamp":1771256260683,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Renal dysfunction is a common complication of liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>), related to hepatorenal syndrome with end\u2010stage liver disease or calcineurin\u2010inhibitor nephrotoxicity. Chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) is also a common problem in long\u2010term survivors post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. This study was done to investigate the association between renal functional status soon after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> and the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 63 patients who were aged 18\u2009years or older, and underwent <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ohoku <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital. The estimated glomerular filtration rate (e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) was calculated by the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>odification of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iet in <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>enal <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease study equation for <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before transplantation, 25 patients (39.7%) were diagnosed with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> (e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>, &lt;60\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup>). The incidence of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> was 22.4% (13\/58) at 2\u2009years, 23.2% (13\/56) at 3\u2009years and 22.7% (12\/54) at 5\u2009years. The patients with <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> at 2\u2009years post\u2010transplant were more likely to have a history of glomerulonephritis, and were significantly older at the time of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, compared to those without <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. Levels of e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> of less than 60\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup> in the first month post\u2010transplant and a volume of intraoperative blood loss of more than 300\u2009mL\/kg were predictive factors for the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> at 2\u2009years post\u2010transplant and thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have shown that there is an improvement of renal function in the majority of patients after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>. Regardless of the presence of pre\u2010existing <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, both renal function status at the first month post\u2010transplant and a volume of intraoperative blood loss were predictive factors for the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> at 2\u2009years post\u2010transplant and thereafter.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12339","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T09:05:02Z","timestamp":1396602302000},"page":"220-227","source":"Crossref","is-referenced-by-count":8,"title":["Renal function status in liver transplant patients in the first month post\u2010transplant is associated with progressive chronic kidney disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Kazushige","family":"Sato","sequence":"first","affiliation":[{"name":"Advanced Surgical Science and Technology Division Department of Surgery Graduate School of Medicine University of Tohoku  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kawagishi","sequence":"additional","affiliation":[{"name":"Advanced Surgical Science and Technology Division Department of Surgery Graduate School of Medicine University of Tohoku  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisei","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Advanced Surgical Science and Technology Division Department of Surgery Graduate School of Medicine University of Tohoku  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Ohuchi","sequence":"additional","affiliation":[{"name":"Advanced Surgical Science and Technology Division Department of Surgery Graduate School of Medicine University of Tohoku  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Satomi","sequence":"additional","affiliation":[{"name":"Advanced Surgical Science and Technology Division Department of Surgery Graduate School of Medicine University of Tohoku  Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021744"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200112270-00012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-0012.2003.00132.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181c353e5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.182"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230122"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.04330.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650576"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1001\/archinte.1984.00350210124021","article-title":"Acquired deficiency and urinary excretion of antithrombin III in nephrotic syndrome","volume":"144","author":"Vaziri ND","year":"1984","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_14_1","first-page":"325","article-title":"Mild\u2010to\u2010moderate renal impairment is associated with platelet activation: a cross\u2010sectional study","volume":"70","author":"Thijs A","year":"2008","journal-title":"Clin Nephrol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000216"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000216"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000185938"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0041-1345(01)02747-6","article-title":"Evaluation of acute renal failure in the liver transplantation perioperative period: incidence and impact","volume":"34","author":"Gainza FJ","year":"2002","journal-title":"Transplant Proc"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20903"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04055-1"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000165118.00988.D7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2010.01219.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1994.tb01286.x"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12339","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:10:56Z","timestamp":1696482656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/hepr.12339"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12339","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,20]]}}}