{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:44:00Z","timestamp":1777355040520,"version":"3.51.4"},"reference-count":68,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Aim<\/jats:title>A systematic review and meta\u2010analysis were conducted to explore the role of the methylenetetrahydrofolate reductase (MTHFR<\/jats:styled-content>) C677T<\/jats:italic><\/jats:styled-content> gene mutation and hyperhomocysteinemia in patients with B<\/jats:styled-content>udd\u2013C<\/jats:styled-content>hiari syndrome (BCS<\/jats:styled-content>) and portal vein thrombosis (PVT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>PubMed<\/jats:styled-content>, EMBASE<\/jats:styled-content>, C<\/jats:styled-content>ochrane L<\/jats:styled-content>ibrary and S<\/jats:styled-content>cienceD<\/jats:styled-content>irect databases were searched. Eligible studies should compare the prevalence of the MTHFR C677T<\/jats:styled-content> mutation or hyperhomocysteinemia or the homocysteine levels between BCS<\/jats:styled-content> or non\u2010cirrhotic PVT<\/jats:styled-content> patients and healthy controls or between cirrhotic patients with and without PVT<\/jats:styled-content>. A pooled odds ratio or weighted mean difference with 95% confidence interval was calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 484 articles retrieved, 20 were included. BCS<\/jats:styled-content> and non\u2010cirrhotic PVT<\/jats:styled-content> patients had a higher prevalence of homozygous MTHFR<\/jats:styled-content> mutation than healthy controls. The difference was statistically significant in BCS<\/jats:styled-content> patients, but not in non\u2010cirrhotic PVT<\/jats:styled-content> patients. BCS<\/jats:styled-content> and non\u2010cirrhotic PVT<\/jats:styled-content> patients had a significantly higher prevalence of hyperhomocysteinemia and homocysteine level than healthy controls. Cirrhotic patients with PVT<\/jats:styled-content> had a significantly higher prevalence of homozygous MTHFR<\/jats:styled-content> mutation than those without PVT<\/jats:styled-content>. However, the association between homocysteine level and PVT<\/jats:styled-content> in cirrhotic patients was inconsistent among three studies.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Homozygous MTHFR<\/jats:styled-content> mutation and hyperhomocysteinemia may be associated with the occurrence of BCS<\/jats:styled-content> and non\u2010cirrhotic PVT<\/jats:styled-content>. In addition, homozygous MTHFR<\/jats:styled-content> mutation may increase the risk of PVT<\/jats:styled-content> in cirrhotic patients. However, the current evidence failed to support the association of hyperhomocysteinemia with PVT<\/jats:styled-content> in cirrhotic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12348","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T12:04:42Z","timestamp":1398686682000},"source":"Crossref","is-referenced-by-count":30,"title":["Methylenetetrahydrofolate reductase C677T<\/i><\/scp> gene mutation and hyperhomocysteinemia in Budd\u2013Chiari syndrome and portal vein thrombosis: A systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"44","author":[{"given":"Xingshun","family":"Qi","sequence":"first","affiliation":[{"name":"Xijing Hospital of Digestive Diseases, Fourth Military Medical University Xi'an China"},{"name":"Department of Gastroenterology no. 463 Hospital of Chinese PLA Shenyang 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