{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T22:21:26Z","timestamp":1748211686338},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>A 40\u2010year\u2010old Japanese man visited our hospital after test results indicated elevated hepatobiliary enzymes. He had worked at a printing plant for 8 years and been exposed to organic solvents, including 1,2\u2010dichloropropane (1,2\u2010<jats:styled-content style=\"fixed-case\">DCP<\/jats:styled-content>) and dichloromethane (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>). Abdominal computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) showed an intrahepatic tumor with dilation of the intrahepatic bile duct. He was diagnosed with intrahepatic cholangiocarcinoma. He had no known risk factors for cholangiocarcinoma. Extended left hepatectomy with lymph node dissection was performed and the tumor was histologically diagnosed as well\u2010differentiated adenocarcinoma. A histological examination also showed biliary intraepithelial preneoplastic lesions in non\u2010cancerous liver areas. Two years after surgery, the patient developed jaundice, esophageal varices and ascites. A <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> examination showed liver cirrhosis without recurrence of the cholangiocarcinoma. Although a liver transplantation was planned as a therapeutic option for his liver cirrhosis, his liver failure progressed rapidly and he died before transplantation could be performed. At autopsy, fibrosis was found in the whole liver, especially in the wall of the bile duct and periductal area suggesting chronic bile duct injury due to exposure to organic solvents. Taken together, the current case may suggest that exposure to organic solvents, including 1,2\u2010<jats:styled-content style=\"fixed-case\">DCP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>, is a risk factor for cholangiocarcinoma. Identifying risk factors for cholangiocarcinoma will help identify the mechanism and help prevent development of the disease.<\/jats:p>","DOI":"10.1111\/hepr.12363","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T09:05:33Z","timestamp":1400749533000},"page":"488-493","source":"Crossref","is-referenced-by-count":8,"title":["Intrahepatic cholangiocarcinoma in a worker at an offset color proof\u2010printing company: An autopsy case report"],"prefix":"10.1111","volume":"45","author":[{"given":"Yoshito","family":"Tomimaru","sequence":"first","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Osaka University  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Osaka University  Suita 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