{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:55:23Z","timestamp":1780084523850,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,1]]},"abstract":"The aim of this study was to assess the efficiency and safety of combination therapy of ursodeoxycholic acid (UDCA<\/jats:styled-content>) and bezafibrate for primary biliary cirrhosis. A meta\u2010analysis of all long\u2010term randomized controlled trials comparing the combination of UDCA<\/jats:styled-content> and bezafibrate with UDCA<\/jats:styled-content> monotherapy was performed via electronic searches. Seven trials, which included 177 patients, were assessed. Combination therapy with UDCA<\/jats:styled-content> and bezafibrate was more effective than UDCA<\/jats:styled-content> monotherapy in improving liver biochemistry, alkaline phosphatase (mean difference [MD<\/jats:styled-content>], \u2212146.15\u2009IU<\/jats:styled-content>\/L; 95% confidence interval [CI<\/jats:styled-content>], \u2212193.58 to \u221298.72; P<\/jats:italic>\u2009<\u20090.00001), \u03b3\u2010glutamyltransferase (MD<\/jats:styled-content>, \u221220.64\u2009IU<\/jats:styled-content>\/L; 95% CI<\/jats:styled-content>, \u221230.86 to \u221210.43; P<\/jats:italic>\u2009<\u20090.0001), immunoglobulin M<\/jats:styled-content> (MD<\/jats:styled-content>, \u221290.96\u2009mg\/dL; 95% CI<\/jats:styled-content>, \u2212137.36 to \u221244.56; P<\/jats:italic>\u2009=\u20090.0001) and triglycerides (MD<\/jats:styled-content>, \u221215.49\u2009mg\/dL; 95% CI<\/jats:styled-content>, \u221230.25 to \u22120.74; P<\/jats:italic>\u2009=\u20090.04). However, their effects on pruritus (odds ratio [OR<\/jats:styled-content>], 0.82; 95% CI<\/jats:styled-content>, 0.30\u20132.24; P<\/jats:italic>\u2009=\u20090.70) and alanine aminotransferase (MD<\/jats:styled-content>, \u22128.41\u2009IU<\/jats:styled-content>\/L; 95% CI<\/jats:styled-content>, \u221222.57 to 5.75; P<\/jats:italic>\u2009=\u20090.24) did not differ significantly. This meta\u2010analysis revealed no significant differences in the incidence of all\u2010cause mortality (OR<\/jats:styled-content>, 0.72; 95% CI<\/jats:styled-content>, 0.10\u20135.49; P<\/jats:italic>\u2009=\u20090.75) and adverse events (OR<\/jats:styled-content>, 0.35; 95% CI<\/jats:styled-content>, 0.07\u20131.84; P<\/jats:italic>\u2009=\u20090.22) between patients treated with combination therapy and those treated with monotherapy. In this meta\u2010analysis, combination therapy with UDCA<\/jats:styled-content> and bezafibrate was more effective than UDCA<\/jats:styled-content> monotherapy. Combination therapy improved liver biochemistry, but did not improve clinical symptoms, incidence of death or adverse events more effectively than monotherapy.<\/jats:p>","DOI":"10.1111\/hepr.12373","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T13:28:25Z","timestamp":1403011705000},"page":"48-58","source":"Crossref","is-referenced-by-count":23,"title":["Combination therapy of bezafibrate and ursodeoxycholic acid for primary biliary cirrhosis: A meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Clinical Medical College of Shanghai Tenth People's Hospital of Nanjing Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(03)00102-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00297.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05270.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/384039a0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.052928"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26155"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00232.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.08.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/236963"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_6_14_1","unstructured":"GluudC NikolovaD KlingenbergSL AlexakisN AlsNielsenB ColliA.Cochrane Hepato\u2010Biliary Group about the cochrane collaboration (Cochrane Review Groups (CRGs))2011; Issue 10. Art. No.: LIVER."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-11-200112040-00010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01667.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-002-1102-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.04.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00305.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181c115b3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06737.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26018"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020981"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1379"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1690453"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/781348"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.10.007"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.03.013"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/187070"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/706156"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12373","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:13:23Z","timestamp":1696338803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,28]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/hepr.12373"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12373","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,28]]}}}