{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T13:54:48Z","timestamp":1769435688966,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Although neonatal hemochromatosis (<jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content>) is a well\u2010known cause of liver failure during the neonatal period and iron deposition in extrahepatic tissues is considered essential in the diagnosis of <jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content>, there is no consensus regarding the pathology or diagnostic criteria of <jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content>. Recent studies of immunohistochemical assays have shown that the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 complex (the terminal membrane attack complement complex) is strongly expressed in the liver of <jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content> cases, suggesting that a gestational alloimmune mechanism is the cause of liver injury. The patient was a low birthweight primiparous male born at 37 weeks of gestation by vaginal delivery. Blood tests 3\u2009h after birth showed signs of liver failure, including high transferrin saturation, resembling the clinical characteristics of <jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content>. However, magnetic resonance imaging and a lip biopsy showed no obvious iron deposition outside the liver. The patient was refractory to exchange transfusion and immunoglobulin therapy but was successfully treated by liver transplantation. Histologically, the explanted liver showed established cirrhosis, with large amounts of human <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>5b\u20109 in the residual hepatocytes, suggesting the alloimmune mechanism of liver injury was the cause of his liver failure. Liver failure caused by a gestational alloimmune mechanism should be considered in patients with antenatal liver failure, even without obvious extrahepatic siderosis.<\/jats:p>","DOI":"10.1111\/hepr.12381","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:27:00Z","timestamp":1404174420000},"page":"601-605","source":"Crossref","is-referenced-by-count":14,"title":["Neonatal liver failure owing to gestational alloimmune liver disease without iron overload"],"prefix":"10.1111","volume":"45","author":[{"given":"Tomoyuki","family":"Tsunoda","sequence":"first","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama Eastern Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Inui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama Eastern Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manari","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama Eastern Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Sogo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama Eastern Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toho University Medical Center Sakura Hospital  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama Eastern Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20497"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23581"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70310-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05669.x"},{"key":"e_1_2_5_6_1","first-page":"325","article-title":"Gestational alloimmune liver disease and neonatal hemochromatosis","volume":"32","author":"Whitington PF","year":"2012","journal-title":"Semin Liver Dis"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.04.012"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17356-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.119989"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91110-R"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21129"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000162004.44971.92"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0568"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12381","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:44:53Z","timestamp":1696319093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/hepr.12381"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12381","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,29]]}}}