{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:03Z","timestamp":1793059983810,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T00:00:00Z","timestamp":1412812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Aim<\/jats:title>The transfusion transmission of hepatitis E<\/jats:styled-content> can occur even in non\u2010endemic areas in the world as autochthonous hepatitis E<\/jats:styled-content> has been increasingly reported in developed countries where the hepatitis E<\/jats:styled-content> virus (HEV<\/jats:styled-content>) is not prevalent. We investigated the post\u2010transfusion transmission of hepatitis E<\/jats:styled-content> in a patient by molecularly confirming its presence, and characterized the viral kinetics of HEV<\/jats:styled-content> in this case.<\/jats:p><\/jats:sec>Methods<\/jats:title>A J<\/jats:styled-content>apanese man underwent re\u2010thoracotomy for hemostasis followed by platelet transfusion. After the transfusion, the blood donor was found to be HEV<\/jats:styled-content> positive. The donated blood was re\u2010examined and was found to contain HEV<\/jats:styled-content>. Throughout the prospective follow up of the patient, we analyzed the viral kinetics, chronological anti\u2010HEV<\/jats:styled-content> antibody level changes and disease progression during the entire course of HEV<\/jats:styled-content> infection from transfusion until the end of viremia.<\/jats:p><\/jats:sec>Results<\/jats:title>Sequence analysis of the strains isolated from both the donor and the patient who contracted acute hepatitis E<\/jats:styled-content> showed an identical match for 326\u2009nucleotides in open reading frame 1. Two strains belonged to HEV<\/jats:styled-content> genotype 3 indigenous to J<\/jats:styled-content>apan.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>To the best of our knowledge, this is the first detailed report on the entire natural course of hepatitis E<\/jats:styled-content> from viral transmission, then clearance, to replication preceding liver injury caused by HEV<\/jats:styled-content> genotype 3, which is responsible for autochthonous infection in developed countries. The findings provide valuable insights into the mechanism of the transfusion transmission of HEV<\/jats:styled-content> and subsequent viral dynamics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12390","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T11:16:55Z","timestamp":1405595815000},"page":"698-704","source":"Crossref","is-referenced-by-count":33,"title":["Rare case of transfusion\u2010transmitted hepatitis E<\/scp> from the blood of a donor infected with the hepatitis E<\/scp> virus genotype 3 indigenous to J<\/scp>apan: Viral dynamics from onset to recovery"],"prefix":"10.1111","volume":"45","author":[{"given":"Takeshi","family":"Matsui","sequence":"first","affiliation":[{"name":"Center for Gastroenterology Teine Keijinkai Hospital Sapporo Japan"},{"name":"Department of Virology Nagoya City University Graduate School of Medical Sciences Nagoya 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