{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T17:27:52Z","timestamp":1780766872713,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Ministry of Health, Labour and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Patients with autoimmune hepatitis (<jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>) sometimes relapse after immunosuppressive therapies are discontinued or sometimes even while they are still being administrated. Furthermore, relapse often occurs in the absence of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> relapse risk factors. This study aimed to identify the frequency of relapse and to analyze the risk factors associated with relapse in type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical characteristics and therapeutic processes were assessed in 129 type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relapse was identified in 39 (30.2%) type 1 <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients after alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) level normalization. <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> levels significantly increased when corticosteroid treatment was initiated in relapsed patients compared with that in patients with sustained remission. The reduction dose and rate of corticosteroid taper were significantly increased in relapsed patients compared with those in sustained remission patients. Moreover, positive correlations were identified between the reduction dose\/taper rate and initial corticosteroid dose, and <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> levels, total bilirubin levels and hepatitis activity. Multivariate logistic regression analysis identified the corticosteroid reduction rate as significantly associated with <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Corticosteroid reduction taper rate until <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> normalization is an important <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> relapse risk factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12397","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T06:55:23Z","timestamp":1406616923000},"page":"638-644","source":"Crossref","is-referenced-by-count":9,"title":["Rapid corticosteroid tapering: Important risk factor for type 1 autoimmune hepatitis relapse in <scp>J<\/scp>apan"],"prefix":"10.1111","volume":"45","author":[{"given":"Atsushi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, 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