{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:15:52Z","timestamp":1781741752020,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p>Gastrinomas mainly occur in the duodenum and pancreas. Primary hepatic gastrinoma is rare and difficult to diagnose because the liver is a frequent site of metastatic gastrinomas. Clinical factors were assessed in a 28\u2010year\u2010old man with diarrhea and heartburn who was hospitalized for recurrent duodenal ulcers. Abdominal ultrasound, endoscopic ultrasound and computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) could not detect a tumor in the duodenum or pancreas. His gastrin level was 846\u2009pg\/mL and magnetic resonance imaging showed a mass 12\u2009mm in diameter in the right robe of the liver. A selective intra\u2010arterial calcium injection (<jats:styled-content style=\"fixed-case\">SACI<\/jats:styled-content>) test and 68\u2010gallium edotreotide positron emission tomography<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">DOTATOC PET\u2010CT<\/jats:styled-content>) were therefore performed. Calcium gluconate injection into the proper hepatic artery resulted in a marked increase in serum gastrin concentration in the right hepatic vein, with<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>a\u2010<jats:styled-content style=\"fixed-case\">DOTATOC PET\u2010CT<\/jats:styled-content>showing uptake only by the liver mass. Following a diagnosis of primary hepatic gastrinoma, the tumor was resected. A histopathological examination indicated gastrinoma. Six months postoperatively, he has no symptoms, is not taking proton\u2010pump inhibitors and his gastrin level remains within the normal range. The<jats:styled-content style=\"fixed-case\">SACI<\/jats:styled-content>test and the clinical course of this patient strongly suggest that the tumor was a primary hepatic gastrinoma. The<jats:styled-content style=\"fixed-case\">SACI<\/jats:styled-content>test is helpful in the diagnosis of primary hepatic gastrinoma.<\/jats:p>","DOI":"10.1111\/hepr.12404","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T10:14:12Z","timestamp":1408702452000},"page":"823-826","source":"Crossref","is-referenced-by-count":15,"title":["Case of primary hepatic gastrinoma: Diagnostic usefulness of the selective arterial calcium injection test"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-4212","authenticated-orcid":false,"given":"Satoshi","family":"Ogawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Shimeno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hobyung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kobe City Medical Center General Hospital Kobe 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Surgery Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyo","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Radiology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Pathology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"bcr.01.2009.152","DOI":"10.1136\/bcr.01.2009.1529","article-title":"A case of recurrent gastrinoma in the liver with a review of \u201cprimary\u201d hepatic 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