{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T15:52:05Z","timestamp":1709308325924},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>We report a female patient with acute hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> due to horizontal transmission of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> virus from her husband, who suffered from de novo hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. A 48\u2010year\u2010old man underwent peripheral blood stem cell transplantation (<jats:styled-content style=\"fixed-case\">PBSCT<\/jats:styled-content>) for adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell leukemia\/lymphoma. Nine months after the initial treatment, he was referred to our hospital because of jaundice. Laboratory data showed elevated serum aminotransferase levels and hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> surface antigen (<jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content>) positivity. We diagnosed de novo hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> because a pre\u2010<jats:styled-content style=\"fixed-case\">PBSCT<\/jats:styled-content> serum sample was negative for <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> and positive for anti\u2010hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> core antibody (<jats:styled-content style=\"fixed-case\">HBcAb<\/jats:styled-content>). His liver function improved with entecavir therapy. Two months after his diagnosis of hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, his 31\u2010year\u2010old wife was admitted with fever and appetite loss. She was diagnosed with acute hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> because of increased serum aminotransferase levels and <jats:styled-content style=\"fixed-case\">HBsAg<\/jats:styled-content> and immunoglobulin <jats:styled-content style=\"fixed-case\">M HBcAb<\/jats:styled-content> positivity. Sequencing of <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> in the serum obtained from both patients showed 99.9% homology. Therefore, we diagnosed her acute hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> as due to horizontal transmission of de novo hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> from her husband. <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> derived from de novo hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> should be considered a potential source of infection, although intrafamilial transmission of de novo hepatitis <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> is rare.<\/jats:p>","DOI":"10.1111\/hepr.12422","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T13:53:44Z","timestamp":1410443624000},"page":"933-938","source":"Crossref","is-referenced-by-count":1,"title":["Horizontal transmission of de novo hepatitis <scp>B<\/scp> between spouses: A case 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