{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:47:05Z","timestamp":1789001225779,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study is to evaluate the factors influencing biochemical response to treatment and the value of biochemical response for predicting long\u2010term outcomes in Japanese patients with primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Biochemical response to ursodeoxycholic acid (<jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> plus bezafibrate was defined as good (\u2264upper limit of normal [<jats:styled-content style=\"fixed-case\">ULN<\/jats:styled-content>]), fair (\u22641.5\u2009\u00d7\u2009<jats:styled-content style=\"fixed-case\">ULN<\/jats:styled-content>) or poor (&gt;1.5\u2009\u00d7\u2009<jats:styled-content style=\"fixed-case\">ULN<\/jats:styled-content>) at 2 years after initiation of <jats:styled-content style=\"fixed-case\">UDCA<\/jats:styled-content> treatment. Associations between various factors (including age, sex, autoantibody status and histological variables at baseline), biochemical response to treatment and long\u2010term outcomes were evaluated in 164 Japanese <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010gp210 positivity and a higher bile duct loss score were significant risk factors for worse alkaline phosphatase (<jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content>) response (odds ratios [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>], 2.78 and 1.85, respectively). Age, anti\u2010gp210 positivity and anticentromere positivity were significant risk factors for worse alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) response (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.05, 4.0 and 2.77, respectively). Anti\u2010gp210 positivity and a higher hepatitis score were significant risk factors for worse immunoglobulin (<jats:styled-content style=\"fixed-case\">Ig<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content> response (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.10 and 2.06, respectively). Worse <jats:styled-content style=\"fixed-case\">ALP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> response were significant risk factors for progression to late\u2010stage disease without jaundice (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.27 and 2.32, respectively). Worse <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> response was a significant risk factor for progression to late\u2010stage disease with persistent jaundice (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 11.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Biochemical response to treatment at 2 years, which is influenced by autoantibody status and histological variables at baseline, can predict long\u2010term outcomes in Japanese patients with <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12423","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T03:21:00Z","timestamp":1410751260000},"page":"846-855","source":"Crossref","is-referenced-by-count":43,"title":["Autoantibody status and histological variables influence biochemical response to treatment and long\u2010term outcomes in <scp>J<\/scp>apanese patients with primary biliary cirrhosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Minoru","family":"Nakamura","sequence":"first","affiliation":[{"name":"Clinical Research Center in National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology Nagasaki University Graduate School of Biomedical Sciences  Omura Japan"},{"name":"Headquaters of gp210 working in Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labor and Welfare of Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisayoshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Atomic Bomb Disease Institute Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumasa","family":"Komori","sequence":"additional","affiliation":[{"name":"Clinical Research Center in National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology Nagasaki University Graduate School of Biomedical Sciences  Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Clinical Research Center in National Hospital Organization (NHO) Nagasaki Medical Center and Department of Hepatology Nagasaki University Graduate School of Biomedical Sciences  Omura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama 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