{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:01Z","timestamp":1790263621985,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Aim<\/jats:title>To investigate the association between primary biliary cirrhosis (PBC<\/jats:styled-content>) and risk of coronary artery disease (CAD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a systematic review and meta\u2010analysis of published observational studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratios with 95% confidence intervals (CI<\/jats:styled-content>) comparing CAD<\/jats:styled-content> risk in patients with PBC<\/jats:styled-content> versus non\u2010PBC<\/jats:styled-content> controls. Pooled risk ratios and 95% confidence intervals were combined using a random\u2010effect model and generic inverse variance of DerSimonian<\/jats:styled-content> and L<\/jats:styled-content>aird methods.<\/jats:p><\/jats:sec>Result<\/jats:title>Four studies with 3362 patients with PBC<\/jats:styled-content> were identified and included in our data analysis. The pooled risk ratio of CAD<\/jats:styled-content> in patients with PBC<\/jats:styled-content> was 1.57 (95% CI<\/jats:styled-content>, 1.21\u20132.06). The statistical heterogeneity was low with an I2<\/jats:sup><\/jats:styled-content> of 38%.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study demonstrated a statistically significant increased risk of CAD<\/jats:styled-content> among patients with PBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12452","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T11:13:46Z","timestamp":1416395626000},"page":"1055-1061","source":"Crossref","is-referenced-by-count":30,"title":["Coronary artery disease in primary biliary cirrhosis: A systematic review and meta\u2010analysis of observational studies"],"prefix":"10.1111","volume":"45","author":[{"given":"Patompong","family":"Ungprasert","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Mayo Clinic Rochester Minnesota USA"},{"name":"Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karn","family":"Wijarnpreecha","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Unit Department of Physiology Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasin","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ittikorn","family":"Spanuchart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine John A. 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