{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:03:36Z","timestamp":1790096616459,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Vehicle Racing Commemorative Foundation, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Aim<\/jats:title>\n \n Recent studies have indicated that hepatocellular adenoma (\n HCA<\/jats:styled-content>\n ) is a heterogenous group of benign tumors with various genetic and clinicopathological characteristics. We delineated the clinicopathological characteristics of\n HCA<\/jats:styled-content>\n subtypes and evaluated the expression of transporter protein\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 in\n HCA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n HCA<\/jats:styled-content>\n in 34\n J<\/jats:styled-content>\n apanese patients were investigated immunohistochemically and classified into four subtypes (\n HNF<\/jats:styled-content>\n 1\u03b1\u2010inactivated type,\n H<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n ; \u03b2\u2010catenin\u2010activated type, b\u2010\n HCA<\/jats:styled-content>\n ; inflammatory type,\n I<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n ; unclassified type, u\u2010\n HCA<\/jats:styled-content>\n ). Immunostaining of\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 protein in\n HCA<\/jats:styled-content>\n tissue sections was performed to determine the association between\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 expression and\n HCA<\/jats:styled-content>\n subtypes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HCA<\/jats:styled-content>\n was categorized into the following four subtypes and two combined subtypes: 10\n H<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n (29%), 10\n I<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n (29%), seven b\u2010\n HCA<\/jats:styled-content>\n (21%), two b\u2010\n HCA<\/jats:styled-content>\n \/\n H<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n (6%), two b\u2010\n HCA<\/jats:styled-content>\n \/\n I<\/jats:styled-content>\n \u2010\n HCA<\/jats:styled-content>\n (6%) and three u\u2010\n HCA<\/jats:styled-content>\n (9%). The male\u2010to\u2010female ratio was 18:16. Oral contraceptive use was rare but seven\n HCA<\/jats:styled-content>\n were found in patients with glycogen storage disease, congenital absence of the portal vein and idiopathic portal hypertension.\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 expression was decreased in 24\n HCA<\/jats:styled-content>\n but was preserved or increased in 10\n HCA<\/jats:styled-content>\n . All nine\n HCA<\/jats:styled-content>\n with nuclear staining for \u03b2\u2010catenin showed preserved or enhanced\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 expression, indicating a significant association between nuclear \u03b2\u2010catenin accumulation and\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 expression in\n HCA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n HCA<\/jats:styled-content>\n subtype classification was validated in 91% of our\n J<\/jats:styled-content>\n apanese subjects although their clinical backgrounds including rare contraceptive use were different from\n E<\/jats:styled-content>\n uropean subjects. A close association between preserved or enhanced\n OATP<\/jats:styled-content>\n 1\n B<\/jats:styled-content>\n 3 expression and b\u2010\n HCA<\/jats:styled-content>\n subtype indicated important modalities for clinical decisions in the treatment and follow up of patients with\n HCA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hepr.12453","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T02:08:49Z","timestamp":1416794929000},"source":"Crossref","is-referenced-by-count":35,"title":["Preserved or enhanced\n OATP1B3<\/scp>\n expression in hepatocellular adenoma subtypes with nuclear accumulation of \u03b2\u2010catenin"],"prefix":"10.1111","volume":"45","author":[{"given":"Toshio","family":"Fukusato","sequence":"first","affiliation":[{"name":"Department of Pathology Teikyo University School of Medicine Tokyo 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