{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:48:41Z","timestamp":1771652921575,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Hepatic amyloid light\u2010chain (<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>) amyloidosis is characterized by abnormal deposition of amyloid fibrils in the liver. As this precursor protein is produced by a proliferative plasma cell clone in the bone marrow, liver transplantation (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) does not affect the disease's progression. Here, we describe the successful treatment using bortezomib\u2010 and dexamethasone\u2010based chemotherapy, following <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, of hepatic <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> amyloidosis in a 65\u2010year\u2010old woman with progressive liver failure. The patient presented with progressive hepatic dysfunction accompanied by hepatorenal syndrome requiring hemodialysis, and living donor <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> was successfully performed. Histology revealed amyloid deposits in the liver and stomach, and serum immunofixation revealed <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> amyloidosis (\u03ba\u2010type). The patient began chemotherapy on day 45 after the <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, and remission was achieved after one course. She was subsequently discharged 83\u2009days after the <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, with normal liver and renal function, and no clinical evidence of recurrent disease was observed at the latest follow up (22\u2009months post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>).<\/jats:p>","DOI":"10.1111\/hepr.12462","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T06:58:09Z","timestamp":1418972289000},"source":"Crossref","is-referenced-by-count":8,"title":["Treatment of hepatic amyloid light\u2010chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient"],"prefix":"10.1111","volume":"45","author":[{"given":"Ryosuke","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Ohira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ide","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Research Center for Radiation Casualty Medicine Research Institute for Radiation Biology and Medicine Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Research Center for Radiation Casualty Medicine Research Institute for Radiation Biology and Medicine Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Arihiro","sequence":"additional","affiliation":[{"name":"Department of Pathology Graduate School of Biomedical Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohdan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery Applied Life Sciences Institute of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"186","article-title":"amyloidosis. 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