{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:37:24Z","timestamp":1740112644665,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Aim<\/jats:title>Presence of portal hypertension (PH<\/jats:styled-content>) adversely affects perioperative and long\u2010term outcome in patients with post\u2010cholecystectomy benign biliary stricture (PCBBS<\/jats:styled-content>). Identification of factors related to the development of PH<\/jats:styled-content> will help to prevent this complication.<\/jats:p><\/jats:sec>Methods<\/jats:title>From S<\/jats:styled-content>eptember 2010 to D<\/jats:styled-content>ecember 2012, 30 patients with PCBBS<\/jats:styled-content> were studied prospectively for correlation of portal pressure (PP<\/jats:styled-content>) with injury repair interval (IRI<\/jats:styled-content>), biliary pressure (BP<\/jats:styled-content>), severity of hepatic fibrosis (FS<\/jats:styled-content>), severity of hepatic inflammation (IS<\/jats:styled-content>) and obstructive biliary pathology score (OBPS<\/jats:styled-content>). Appropriate statistical methods employed and P<\/jats:styled-content><\/jats:italic>\u2009\u2264\u20090.05 (two\u2010sided) was considered statistically significant.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean PP<\/jats:styled-content>, mean BP<\/jats:styled-content> and median IRI<\/jats:styled-content> were 19.4\u2009\u00b1\u20094.74\u2009mmHg, 20.1\u2009\u00b1\u20093.99\u2009mmHg and 145 days, respectively. Spearman's rank correlation coefficients (P<\/jats:styled-content>\u2010<\/jats:italic>value) of PP<\/jats:styled-content> with IRI<\/jats:styled-content>, FS<\/jats:styled-content>, IS<\/jats:styled-content> and OBPS<\/jats:styled-content> were 0.564 (0.001), 0.502 (0.004), 0.752 (0.0001) and 0.242 (0.19), respectively. Pearson correlation of PP<\/jats:styled-content> with BP<\/jats:styled-content> was r<\/jats:italic>\u2009=\u20090.383 (r<\/jats:italic>2<\/jats:sup>\u2009=\u20090.146, P<\/jats:italic>\u2009=<\/jats:italic>\u20090.03). Spearman's rank correlation coefficients (P<\/jats:italic>\u2010value) of FS<\/jats:styled-content> with IS<\/jats:styled-content> and OBPS<\/jats:styled-content> were 0.561 (0.003) and 0.371 (0.04), respectively. Spearman's rank correlation coefficient of serum bilirubin with OBPS<\/jats:styled-content> was 0.550 (P<\/jats:italic>\u2009=\u20090.001). Incidence of PH<\/jats:styled-content> was 33.3% and mean fall of PP<\/jats:styled-content> following biliary repair was 6.2\u2009\u00b1\u20091.98\u2009mmHg (P<\/jats:italic>\u2009<\u20090.0001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PP<\/jats:styled-content> in patients with PCBBS<\/jats:styled-content> has a good correlation with IS<\/jats:styled-content>, and a fair correlation with both FS<\/jats:styled-content> and IRI<\/jats:styled-content> whereas PP<\/jats:styled-content> was not directly related to BP<\/jats:styled-content> and OBPS<\/jats:styled-content>; further prospective trials are mandatory to confirm this correlation, and to evaluate mechanism of fall in PP<\/jats:styled-content> following biliary decompression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12463","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T03:09:19Z","timestamp":1419390559000},"source":"Crossref","is-referenced-by-count":1,"title":["Correlations of portal pressure in post\u2010cholecystectomy benign biliary stricture"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-7752","authenticated-orcid":false,"given":"Hirdaya H.","family":"Nag","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asit","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ila","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Pathology Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja","family":"Sakhuja","sequence":"additional","affiliation":[{"name":"Department of Pathology Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renuka","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Statistics Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Govind Ballabh Pant Hospital and M A M College Delhi University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1002\/bjs.1800711110"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1001\/archsurg.1995.01430060035007"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/j.amjsurg.2007.03.013"},{"key":"e_1_2_6_5_1","first-page":"G312","article-title":"Biliary obstruction dissipates bioelectric sinusoidal\u2010canalicular barrier without altering taurocholate uptake","volume":"256","author":"Cotting J","year":"1989","journal-title":"Am J Physiol"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1172\/JCI114886"},{"key":"e_1_2_6_7_1","first-page":"888","article-title":"Mechanism of cholestasis 4. 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