{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:03:40Z","timestamp":1780085020062,"version":"3.54.0"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T00:00:00Z","timestamp":1429056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan","award":["Grant-in-Aid H24-kanen-004 to M.\u2009M."],"award-info":[{"award-number":["Grant-in-Aid H24-kanen-004 to M.\u2009M."]}]},{"DOI":"10.13039\/501100001700","name":"the Ministry of Education, Culture, Sports Science and Technology of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grant-in-Aid for Scientific Research","award":["24591428"],"award-info":[{"award-number":["24591428"]}]},{"name":"National Cancer Center Research and Development Fund","award":["26-A-4 to T.\u2009I."],"award-info":[{"award-number":["26-A-4 to T.\u2009I."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>We report an adult T\u2010cell leukemia\u2013lymphoma (ATL) patient suffering from fatal reactivation of hepatitis B virus (HBV) infection after treatment with the anti\u2010CC chemokine receptor 4 (CCR4) monoclonal antibody, mogamulizumab. HBV reactivation occurred without liver damage in this hepatitis B surface antigen (HBsAg) negative patient, who was seropositive for antibodies against the viral core and surface antigens at baseline, after two cycles of CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisolone) followed by six cycles of THP\u2010COP regimen (cyclophosphamide, pirarubicin, vincristine and prednisolone). Unexpectedly, mogamulizumab monotherapy for relapsed CCR4 positive ATL induced sudden and fatal liver failure due to HBV reactivation, despite antiviral prophylaxis with entecavir. This clinical course may not only offer important suggestions to prevent critical HBV reactivation in HBsAg positive cancer patients who receive immune\u2010enhancing drugs such as anti\u2010CCR4 antibody, but also provide a clue to understanding the pathogenesis of HBV reactivation following systemic chemotherapy.<\/jats:p>","DOI":"10.1111\/hepr.12513","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T03:38:52Z","timestamp":1425958732000},"page":"1363-1367","source":"Crossref","is-referenced-by-count":37,"title":["Fatal reactivation of hepatitis B virus infection in a patient with adult T\u2010cell leukemia\u2013lymphoma receiving the anti\u2010CC chemokine receptor 4 antibody mogamulizumab"],"prefix":"10.1111","volume":"45","author":[{"given":"Hideki","family":"Ifuku","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Amagasaki Central Hospital  Hyogo 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