{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:55:47Z","timestamp":1778504147227,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to examine the relationship between the <jats:italic>Wisteria floribunda<\/jats:italic> agglutinin positive Mac\u20102\u2010binding protein (WFA<jats:sup>+<\/jats:sup>\u2010M2BP) level and high\u2010sensitivity C\u2010reactive protein (hCRP) concentration and liver histological findings for patients with autoimmune hepatitis (AIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 84 AIH patients (median age, 64\u00a0years) were analyzed. We examined the effect of pretreatment WFA<jats:sup>+<\/jats:sup>\u2010M2BP level and hCRP concentration on histological findings of liver fibrosis and liver inflammation activity comparing with other laboratory markers. Receiver\u2013operator curve (ROC) analysis was performed for calculating the area under the ROC (AUROC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median WFA<jats:sup>+<\/jats:sup>\u2010M2BP values in each fibrosis stage were: 1.5 cut\u2010off index (COI) in F1, 2.1 in F2, 3.3 in F3 and 9.8 in F4 (<jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001). The median WFA<jats:sup>+<\/jats:sup>\u2010M2BP values in each liver inflammation stage were: 1.6 COI in A1, 2.5 in A2 and 5.4 in A3 (<jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001). For predicting liver cirrhosis (F4), WFA<jats:sup>+<\/jats:sup>\u2010M2BP yielded the highest AUROC (0.853). For predicting advanced liver fibrosis (F3 or F4), WFA<jats:sup>+<\/jats:sup>\u2010M2BP, FIB\u20104 index and hyaluronic acid yielded the highest AUROC (0.747). For predicting severe liver inflammation activity (A3), WFA<jats:sup>+<\/jats:sup>\u2010M2BP yielded the highest AUROC (0.739). The hCRP concentration in patients with A3 (median, 2230\u00a0ng\/mL) was significantly higher than that in patients with A1 or A2 (median, 854.5\u00a0ng\/mL) (<jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.01). WFA<jats:sup>+<\/jats:sup>\u2010M2BP level significantly correlated with hCRP concentration (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u2009=\u20090.461, <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WFA<jats:sup>+<\/jats:sup>\u2010M2BP can be a useful marker for assessing liver histological findings in AIH patients and it correlated well with hCRP concentration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12596","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T21:26:43Z","timestamp":1443216403000},"page":"613-621","source":"Crossref","is-referenced-by-count":76,"title":["Clinical significance of serum <i>Wisteria floribunda<\/i> agglutinin positive Mac\u20102\u2010binding protein level and high\u2010sensitivity C\u2010reactive protein concentration in autoimmune hepatitis"],"prefix":"10.1111","volume":"46","author":[{"given":"Hiroki","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirayuki","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Iwata","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikage","family":"Nakano","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Takata","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Yoh","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Aizawa","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Takashima","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine Hyogo College of Medicine  Hyogo 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