{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:12:39Z","timestamp":1762506759393},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T00:00:00Z","timestamp":1461974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>We report a 60\u2010year\u2010old male patient who developed extrahepatic metastases in bone, peritoneum, and lymph nodes (confirmed by computed tomography and positron emission tomography\u2013computed tomography) after hepatectomy for hepatocellular carcinoma. He was treated with sorafenib (800\u00a0mg\/day) but developed grade 3 hand\u2013foot syndrome. He continued to be treated with sorafenib but at a lower dose (400\u00a0mg\/week). The response to sorafenib therapy was graded as complete response at 6\u00a0months by the Response Evaluation Criteria in Solid Tumors. Sorafenib was continued for 8 months and the patient remained in complete response for 11 months. Further reporting of similar cases should help design treatment strategies and evaluate predictors of the response to sorafenib therapy.<\/jats:p>","DOI":"10.1111\/hepr.12698","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T11:55:42Z","timestamp":1458302142000},"page":"1402-1408","source":"Crossref","is-referenced-by-count":8,"title":["Complete response to short\u2010term sorafenib treatment alone for hepatocellular carcinoma with bone, lymph node, and peritoneum metastases"],"prefix":"10.1111","volume":"46","author":[{"given":"Norihito","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular Science Division of Frontier Medical Science, and, Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomokazu","family":"Kawaoka","sequence":"additional","affiliation":[{"name":"Department of Medicine and Molecular Science Division of Frontier Medical Science, and, 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