{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:02:30Z","timestamp":1789246950943,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the relationship between serum <jats:styled-content style=\"fixed-case\"><jats:italic>Wisteria floribunda<\/jats:italic><\/jats:styled-content> agglutinin\u2010positive Mac\u20102\u2010binding protein (WFA<jats:sup>+<\/jats:sup>\u2010M2BP) levels and liver histological findings for patients with treatment na\u00efve chronic hepatitis B (CHB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 189 treatment na\u00efve\u2010CHB patients were analyzed. We examined the effect of pretreatment serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels on histological findings compared with other laboratory markers, including aspartate aminotransferase (AST) to platelet ratio index, Fibrosis\u20104 index, platelet count, AST to alanine aminotransferase (ALT) ratio, and hyaluronic acid as liver fibrosis markers, and AST value, ALT value, and serum interferon\u2010\u03b3\u2010inducible protein\u201010 level as liver inflammation markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The WFA<jats:sup>+<\/jats:sup>\u2010M2BP value ranged from 0.3 cut\u2010off index (COI) to 12.9 COI (median value, 1.2 COI). The degree of liver fibrosis was significantly stratified according to WFA<jats:sup>+<\/jats:sup>\u2010M2BP level in each group except for groups F2 and F3 and the degree of liver inflammation activity was significantly stratified according to WFA<jats:sup>+<\/jats:sup>\u2010M2BP level in each group. For predicting F4, WFA<jats:sup>+<\/jats:sup>\u2010M2BP level yielded the highest area under the receiver operating characteristic curve (AUROC) with a level of 0.87 and for predicting advanced liver fibrosis (\u2265F3) and significant liver fibrosis (\u2265F2), WFA<jats:sup>+<\/jats:sup>\u2010M2BP level yielded the second highest AUROCs (both, 0.77) among six fibrotic markers. For predicting severe (A3) or significant liver inflammation activity (\u2265A2), AUROCs of WFA<jats:sup>+<\/jats:sup>\u2010M2BP level were 0.78 and 0.76.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The WFA<jats:sup>+<\/jats:sup>\u2010M2BP level can be a useful marker for assessing liver histological findings in patients with treatment\u2010na\u00efve CHB, although it has several limitations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12703","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:13:32Z","timestamp":1458371612000},"page":"204-215","source":"Crossref","is-referenced-by-count":35,"title":["Clinical implications of serum <scp><i>Wisteria floribunda<\/i><\/scp> agglutinin\u2010positive Mac\u20102\u2010binding protein in treatment\u2010na\u00efve chronic hepatitis B"],"prefix":"10.1111","volume":"47","author":[{"given":"Akio","family":"Ishii","sequence":"first","affiliation":[{"name":"Division of 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