{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:02:29Z","timestamp":1789246949991,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title><jats:italic>Aim<\/jats:italic><\/jats:title><jats:p>Serum glycosylated <jats:styled-content style=\"fixed-case\"><jats:italic>Wisteria floribunda<\/jats:italic><\/jats:styled-content> agglutinin\u2010positive Mac\u20102 binding protein (WFA<jats:sup>+<\/jats:sup>\u2010M2BP) is a reliable, non\u2010invasive marker of liver fibrosis. This study assessed the ability of WFA<jats:sup>+<\/jats:sup>\u2010M2BP to diagnose liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and evaluated WFA<jats:sup>+<\/jats:sup>\u2010M2BP as a predictor of hepatocellular carcinoma (HCC) development.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Methods<\/jats:italic><\/jats:title><jats:p>Serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP values were retrospectively evaluated in 112 treatment\u2010na\u00efve patients with HBV\u2010related chronic hepatitis and cirrhosis who had undergone liver biopsy at our hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results<\/jats:italic><\/jats:title><jats:p>Serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP levels were significantly related with liver fibrosis (r\u2009=\u20090.3725, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Fibrosis stage F2, F3, and F4 had a cut\u2010off index of 0.94, 1.26, and 1.26, respectively. For diagnosing F\u2009\u2265\u20092 fibrosis, the area under the receiver\u2013operating characteristic curve for WFA<jats:sup>+<\/jats:sup>\u2010M2BP was 0.713 and comparable with those of other non\u2010invasive fibrosis markers, such as hyaluronic acid, type IV collagen 7S, aspartate aminotransferase\u2010to\u2010platelet ratio index, fibrosis\u20104 index, serum albumin, and platelet count. Multivariate analysis identified male, WFA<jats:sup>+<\/jats:sup>\u2010M2BP \u22650.71, alanine aminotransferase \u226580\u00a0IU\/L, and platelet count &lt;14.5\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L as independent risk factors for the development of HCC in patients with HBV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum WFA<jats:sup>+<\/jats:sup>\u2010M2BP values appear to be useful for assessing liver fibrosis stage and are independently associated with HCC development in patients with chronic HBV infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12712","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:48:54Z","timestamp":1459381734000},"page":"226-233","source":"Crossref","is-referenced-by-count":45,"title":["Serum <scp><i>Wisteria floribunda<\/i><\/scp> agglutinin\u2010positive human Mac\u20102 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection"],"prefix":"10.1111","volume":"47","author":[{"given":"Yuki","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Shobugawa","sequence":"additional","affiliation":[{"name":"Division of International Health 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