{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:07:14Z","timestamp":1769242034897,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Poorly controlled diabetes mellitus (DM) patients sometimes show serum transaminase elevations due to steatohepatitis. However, we experienced four cases with type 1 DM with sharp elevations in serum transaminases that could not be explained by steatohepatitis alone and showed bright liver. They were diagnosed with glycogenic hepatopathy (GH) clinicopathologically. The four patients had a median age of 22.5\u00a0years (range, 19\u201329\u00a0years) and 12.5 (4\u201315)\u2010year histories of type 1 DM and showed marked increases in serum transaminases (aspartate aminotransferase, 698\u00a0U\/L [469\u20132763\u00a0U\/L]; alanine transaminase, 255\u00a0U\/L [216\u2013956 U\/L]). Diabetes mellitus control was poor and hemoglobin A1c was 12.7% (11\u201316.5%). Three cases had a past history of diabetic ketoacidosis. Hepatomegaly and hyperdense liver were seen on computed tomography scans. Magnetic resonance imaging showed low intensity in T2\u2010weighted images. The pathological findings revealed pale and swollen hepatocytes and glycogenated nuclei. The architecture of the liver was preserved, and steatosis and fibrosis were mild. The cytoplasm of hepatocytes stained densely positive with periodic acid\u2013Schiff, and the positive staining disappeared after diastase digestion, suggesting glycogen deposition. No other cause of hepatitis was evident, and the diagnosis was GH. Elevated transaminases improved within 1\u00a0month with good glycemic control. Transaminase elevations were observed several times in three cases with poor glycemic control. Glycogenic hepatopathy is rare, but extremely high serum elevations of transaminases are important to identify clinically. Despite showing a good clinical course in general, GH sometimes recurs and requires strict glycemic control. Clinicians should be aware of and recognize GH when dealing with uncontrolled DM patients.<\/jats:p>","DOI":"10.1111\/hepr.12713","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:49:38Z","timestamp":1459381778000},"source":"Crossref","is-referenced-by-count":19,"title":["Four cases of type 1 diabetes mellitus showing sharp serum transaminase increases and hepatomegaly due to glycogenic hepatopathy"],"prefix":"10.1111","volume":"47","author":[{"given":"Yuichi","family":"Ikarashi","sequence":"first","affiliation":[{"name":"Institute of Gastroenterology, Department of Internal Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Kogiso","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Department of Internal Medicine Tokyo Women's Medical University  Tokyo 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