{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:26:36Z","timestamp":1783632396127,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hepatology Research"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate the effect of yttrium\u201090 radioembolization on the outcome of Asian patients with early to advanced stage hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010two patients were screened and 50 patients (80.6%) were eligible. Response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST), and overall survival was estimated using the Kaplan\u2013Meier method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Barcelona Clinic Liver Cancer (BCLC) stage was A in 40% of patients, B in 24%, and C in 36%; 66% of patients had hepatitis B virus infections. According to RECIST criteria, partial responses occurred in 40% of patients, and stable disease was achieved in 46%. Tumor response was significantly associated with BCLC stage (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). The median overall time to progression was 5.8\u00a0months (range, 0.9\u201346.1\u00a0months). Follow\u2010up treatments after radioembolization were carried out in 31 patients due to remnant HCC (<jats:italic>n<\/jats:italic>\u2009=\u200918) or HCC progression (<jats:italic>n<\/jats:italic>\u2009=\u200913). The median overall survival was 40.9\u00a0months (95% confidence interval, 10.2\u201371.6\u00a0months). Treatment was tolerable except for one lung toxicity and two hepatic toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Yttrium\u201090 radioembolization appears to be well tolerated and effective in Asian patients with BCLC stage A\u2013C HCC. Follow\u2010up treatments after radioembolization can be safely provided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hepr.12759","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T15:06:00Z","timestamp":1465311960000},"page":"387-397","source":"Crossref","is-referenced-by-count":8,"title":["Effect of yttrium\u201090 radioembolization on outcomes in Asian patients with early to advanced stage hepatocellular carcinoma"],"prefix":"10.1111","volume":"47","author":[{"given":"Hyun Young","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, College of Medicine Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Tae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yun","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangheun","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, College of Medicine Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, College of Medicine Yonsei University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Medical Research Institute Pusan National University, Pusan National University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61347-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300629"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000239147.60196.11"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.3.r00mr02761"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23725"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9736-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08649-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24451"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60381-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23944"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-014-9533-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00130-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.11.060"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1994.436"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728766"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181f47583"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27057"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181df0a50"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.06.010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2015.07.019"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29275"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.049"}],"container-title":["Hepatology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhepr.12759","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hepr.12759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:43:36Z","timestamp":1696333416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hepr.12759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/hepr.12759"],"URL":"https:\/\/doi.org\/10.1111\/hepr.12759","archive":["Portico"],"relation":{},"ISSN":["1386-6346","1872-034X"],"issn-type":[{"value":"1386-6346","type":"print"},{"value":"1872-034X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}